Association between higher serum uric acid levels and cognitive function: a systematic review and meta-analysis.

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-08-09 DOI:10.1093/gerona/glaf174

Golam Rabbani,Sheikh M Alif,Zhen Zhou,Joanne Ryan,Nazmul Karim

{"title":"Association between higher serum uric acid levels and cognitive function: a systematic review and meta-analysis.","authors":"Golam Rabbani,Sheikh M Alif,Zhen Zhou,Joanne Ryan,Nazmul Karim","doi":"10.1093/gerona/glaf174","DOIUrl":null,"url":null,"abstract":"BACKGROUND\r\nSerum uric acid (SUA) levels may be associated with cognitive function, but findings have been inconsistent, potentially varying by cognitive domain and sex. We aimed to determine the association of SUA and different domains of cognitive function.\r\n\r\nMETHODS\r\nFive electronic databases were searched to identify relevant peer-reviewed articles. Studies investigating the association between SUA levels and cognitive function were included. Standardised mean difference (SMD) was calculated and separate meta-analyses were conducted for each of the domains. Risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale. Between-study heterogeneity was investigated through subgroup analysis and a meta-regression model using study-level covariates.\r\n\r\nRESULTS\r\nTen prospective cohort and sixteen cross-sectional studies were eligible for inclusion, but only a subset of these studies was included in each meta-analysis. Pooled estimates from cross-sectional studies showed that higher SUA levels were significantly associated with better global cognition (n = 6, SMD = 2.27, 95%CI:1.18-3.35), and learning and memory (n = 4, SMD = 1.49, 95%CI:1.12-1.87). Sensitivity analysis, excluding the study conducted on amyotrophic lateral sclerosis (ALS) patients, resulted in better performance estimates for executive function (n = 4, SMD = 0.51, 95%CI:0.47-0.55) and language (n = 2, SMD = 0.75, 95%CI:0.71-0.79). The pooled result from two prospective cohort studies found a positive relationship between SUA levels and attention (SMD = 0.22, 95%CI:0.07-0.36). SUA levels were associated with executive function and learning and memory in males, and with language in females.\r\n\r\nCONCLUSIONS\r\nHigher SUA levels were associated with better global cognitive performance executive function, learning and memory, attention and language. These findings highlight low SUA levels as a potential useful biomarker for cognitive decline.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"19 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/gerona/glaf174","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

BACKGROUND Serum uric acid (SUA) levels may be associated with cognitive function, but findings have been inconsistent, potentially varying by cognitive domain and sex. We aimed to determine the association of SUA and different domains of cognitive function. METHODS Five electronic databases were searched to identify relevant peer-reviewed articles. Studies investigating the association between SUA levels and cognitive function were included. Standardised mean difference (SMD) was calculated and separate meta-analyses were conducted for each of the domains. Risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale. Between-study heterogeneity was investigated through subgroup analysis and a meta-regression model using study-level covariates. RESULTS Ten prospective cohort and sixteen cross-sectional studies were eligible for inclusion, but only a subset of these studies was included in each meta-analysis. Pooled estimates from cross-sectional studies showed that higher SUA levels were significantly associated with better global cognition (n = 6, SMD = 2.27, 95%CI:1.18-3.35), and learning and memory (n = 4, SMD = 1.49, 95%CI:1.12-1.87). Sensitivity analysis, excluding the study conducted on amyotrophic lateral sclerosis (ALS) patients, resulted in better performance estimates for executive function (n = 4, SMD = 0.51, 95%CI:0.47-0.55) and language (n = 2, SMD = 0.75, 95%CI:0.71-0.79). The pooled result from two prospective cohort studies found a positive relationship between SUA levels and attention (SMD = 0.22, 95%CI:0.07-0.36). SUA levels were associated with executive function and learning and memory in males, and with language in females. CONCLUSIONS Higher SUA levels were associated with better global cognitive performance executive function, learning and memory, attention and language. These findings highlight low SUA levels as a potential useful biomarker for cognitive decline.

查看原文本刊更多论文

高血清尿酸水平与认知功能之间的关系：一项系统回顾和荟萃分析。

背景：血清尿酸（SUA）水平可能与认知功能有关，但研究结果不一致，可能因认知领域和性别而异。我们的目的是确定SUA与认知功能不同领域的关联。方法检索5个电子数据库，检索相关同行评议文章。调查SUA水平与认知功能之间关系的研究也包括在内。计算标准化平均差（SMD），并对每个域进行单独的荟萃分析。偏倚风险采用纽卡斯尔-渥太华质量评估量表进行评估。通过亚组分析和使用研究水平协变量的元回归模型调查研究间异质性。结果10项前瞻性队列研究和16项横断面研究符合纳入条件，但每次荟萃分析仅纳入这些研究的一部分。来自横断面研究的汇总估计显示，较高的SUA水平与更好的整体认知（n = 6, SMD = 2.27, 95%CI:1.18-3.35）和学习和记忆（n = 4, SMD = 1.49, 95%CI:1.12-1.87）显著相关。敏感性分析，排除肌萎缩侧索硬化症（ALS）患者的研究，结果显示执行功能（n = 4, SMD = 0.51, 95%CI:0.47-0.55）和语言（n = 2, SMD = 0.75, 95%CI:0.71-0.79）的表现更好。两项前瞻性队列研究的汇总结果发现，SUA水平与注意力呈正相关（SMD = 0.22, 95%CI:0.07-0.36）。男性的SUA水平与执行功能、学习和记忆有关，女性则与语言有关。结论较高的SUA水平与较好的整体认知能力、执行功能、学习记忆、注意力和语言能力相关。这些发现强调低SUA水平是认知能力下降的潜在有用的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

自引率

0.00%

发文量