Effect of fine needle aspiration biopsy on change in thyroid nodule elasticity.

IF 2.3

Medical ultrasonography Pub Date : 2025-07-29 DOI:10.11152/mu-4533

Mehmet Akçiçek, Nurullah Dağ, Lezan Keskin, Bülent Petik, Serkan Ünlü

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Abstract

Aims: This study aimed to investigate changes in the stiffness of thyroid nodules following fine needle aspiration biopsy (FNAB), using shear wave elastography (SWE), a non-invasive imaging technique utilized in thyroid nodule evaluation.

Material and methods: A total of 82 patients scheduled to undergo FNAB for the first time were included. Ultrasound and SWE examinations were performed before the procedure and again 8 to 10 weeks after FNAB. Nodule stiffness was measured in kilopascals (kPa) during both evaluations, and changes in elasticity were assessed.

Results: The mean SWE stiffness of the nodules significantly decreased from 21.80 ± 11.43 kPa before FNAB to 17.83 ± 9.98 kPa after FNAB (p = 0.001). Smoking status and serum free T3 levels were significantly associated with changes in SWE stiffness (p < 0.05). However, no significant difference was observed between TIRADS 3 and TIRADS 4 categories regarding the change in stiffness (p = 0.223).

Conclusion: This study demonstrates a significant reduction in thyroid nodule stiffness after FNAB as measured by SWE. These post-biopsy changes may lead to potential misinterpretations in subsequent elastographic evaluations, possibly affecting diagnostic accuracy and clinical decision-making.

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细针穿刺活检对甲状腺结节弹性变化的影响。

目的：本研究旨在探讨细针穿刺活检（FNAB）后甲状腺结节硬度的变化，采用剪切波弹性成像（SWE），一种用于甲状腺结节评估的无创成像技术。材料与方法：共纳入82例首次行FNAB的患者。术前和术后8 - 10周分别进行超声和SWE检查。在两次评估中，以千帕斯卡（kPa）为单位测量结节刚度，并评估弹性的变化。结果：结节的平均SWE刚度由FNAB前的21.80±11.43 kPa显著降低至FNAB后的17.83±9.98 kPa （p = 0.001）。吸烟状况和血清游离T3水平与SWE僵硬度的变化显著相关（p < 0.05）。然而，TIRADS 3和TIRADS 4在刚度变化方面没有显著差异（p = 0.223）。结论：本研究表明，通过SWE测量，FNAB后甲状腺结节硬度显著降低。这些活检后的变化可能导致后续弹性成像评估的潜在误解，可能影响诊断准确性和临床决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical ultrasonography

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