{"title":"Association of a Healthy Lifestyle with Risk of Parkinson's Disease and Genetic Predisposition.","authors":"Qirui Jiang, Junyu Lin, Qianqian Wei, Chunyu Li, Ruwei Ou, Lingyu Zhang, Yanbing Hou, Tianmi Yang, Yi Xiao, Shichan Wang, Jiyong Liu, Xiaoting Zheng, Huifang Shang","doi":"10.1159/000547706","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Parkinson's disease (PD) is the second most common neurodegenerative disease with largely unknown etiology. Evaluating the association between a healthy lifestyle with PD and genetic risk is necessary.</p><p><strong>Methods: </strong>The study included 438,241 participants from the UK Biobank, with lifestyle information collected via baseline questionnaires. Polygenic risk scores (PRS) were divided into quartiles. The healthy lifestyle, including alcohol consumption, body mass index, physical activity, sleep duration, sedentary time, social connections, and diet, was categorized into favorable (scoring 6-7), intermediate (scoring 4-5), and unfavorable (scoring ≤3) lifestyles.</p><p><strong>Results: </strong>During an average follow-up of 9.34 years, 2,996 cases were diagnosed with PD. Compared to participants with an unfavorable lifestyle, those with a favorable lifestyle had a significantly lower risk (hazard ratio [HR] 0.862, 95% CI: 0.753-0.986), whereas those with an intermediate lifestyle had no difference in PD risk. Regular physical activity, adequate sleep, and appropriate social connection were protective factors for the risk of PD (HR 0.839, 95% CI: 0.779-0.905; HR 0.921, 95% CI: 0.851-0.997; HR 0.790, 95% CI: 0.698-0.893). Subgroup analysis by PRS showed that adhering to a healthy lifestyle reduced the risk of PD in all subgroups except the low genetic risk (HR 0.673, 95% CI: 0.510-0.889; HR 0.774, 95% CI: 0.611-0.982; HR 0.769, 95% CI: 0.633-0.935). There was an interaction between high genetic risk and lifestyle scores and sleep duration (p = 0.015 and p = 0.024, respectively) and also between sex and sedentary time (p = 0.002).</p><p><strong>Conclusion: </strong>A healthy lifestyle was associated with a lower risk of PD, and it is important to identify the effect of genetic risk and sex on PD significantly influenced by lifestyle.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-12"},"PeriodicalIF":4.0000,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroepidemiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000547706","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Parkinson's disease (PD) is the second most common neurodegenerative disease with largely unknown etiology. Evaluating the association between a healthy lifestyle with PD and genetic risk is necessary.
Methods: The study included 438,241 participants from the UK Biobank, with lifestyle information collected via baseline questionnaires. Polygenic risk scores (PRS) were divided into quartiles. The healthy lifestyle, including alcohol consumption, body mass index, physical activity, sleep duration, sedentary time, social connections, and diet, was categorized into favorable (scoring 6-7), intermediate (scoring 4-5), and unfavorable (scoring ≤3) lifestyles.
Results: During an average follow-up of 9.34 years, 2,996 cases were diagnosed with PD. Compared to participants with an unfavorable lifestyle, those with a favorable lifestyle had a significantly lower risk (hazard ratio [HR] 0.862, 95% CI: 0.753-0.986), whereas those with an intermediate lifestyle had no difference in PD risk. Regular physical activity, adequate sleep, and appropriate social connection were protective factors for the risk of PD (HR 0.839, 95% CI: 0.779-0.905; HR 0.921, 95% CI: 0.851-0.997; HR 0.790, 95% CI: 0.698-0.893). Subgroup analysis by PRS showed that adhering to a healthy lifestyle reduced the risk of PD in all subgroups except the low genetic risk (HR 0.673, 95% CI: 0.510-0.889; HR 0.774, 95% CI: 0.611-0.982; HR 0.769, 95% CI: 0.633-0.935). There was an interaction between high genetic risk and lifestyle scores and sleep duration (p = 0.015 and p = 0.024, respectively) and also between sex and sedentary time (p = 0.002).
Conclusion: A healthy lifestyle was associated with a lower risk of PD, and it is important to identify the effect of genetic risk and sex on PD significantly influenced by lifestyle.
背景：帕金森病（PD）是第二常见的神经退行性疾病，其病因尚不清楚。评估与帕金森病相关的健康生活方式和遗传风险之间的关系是必要的。方法：该研究包括来自英国生物银行的438,241名参与者，他们的生活方式信息通过基线问卷收集。多基因风险评分（PRS）分为四分位数。健康的生活方式，包括饮酒量、BMI、体力活动、睡眠时间、久坐时间、社会关系和饮食，被分为良好（得分6-7）、中等（得分4-5）和不良（得分≤3）生活方式。结果：平均随访9.34年，确诊PD患者2996例。与生活方式不良的参与者相比，生活方式良好的参与者的风险显著降低（HR 0.862, 95% CI 0.753-0.986）。规律的身体活动、充足的睡眠和适当的社会关系是PD风险的保护因素(HR 0.839, 95% CI 0.779-0.905；Hr 0.921, 95% ci 0.851 ~ 0.997；Hr 0.790, 95% ci 0.698-0.893)。PRS的亚组分析显示，除了低遗传风险外，坚持健康的生活方式降低了所有亚组PD的风险(HR 0.673, 95% CI 0.510-0.889；Hr 0.774, 95% ci 0.611-0.982；Hr 0.769, 95% ci 0.633-0.935)。高遗传风险与生活方式评分和睡眠时间之间存在相互作用（分别为P=0.015和P=0.024），性别与久坐时间之间也存在相互作用（P=0.002）。结论：健康的生活方式与较低的PD风险相关，确定遗传风险和性别对受生活方式显著影响的PD的影响具有重要意义。
期刊介绍：
''Neuroepidemiology'' is the only internationally recognised peer-reviewed periodical devoted to descriptive, analytical and experimental studies in the epidemiology of neurologic disease. The scope of the journal expands the boundaries of traditional clinical neurology by providing new insights regarding the etiology, determinants, distribution, management and prevention of diseases of the nervous system.
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