Association of COVID-19 Susceptibility and Severity with Primary Angle-Closure Glaucoma.

IF 1.2 4区医学 Q3 OPHTHALMOLOGY

Ophthalmic epidemiology Pub Date : 2025-08-11 DOI:10.1080/09286586.2025.2547274

Yingting Zhu, Jianqi Chen, Yuwen Wen, Zhidong Li, Yuyao Ling, Yehong Zhuo

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引用次数: 0

Abstract

Purpose: Observational studies have suggested a link between coronavirus disease 2019 (COVID-19) and increased risk for primary angle-closure glaucoma (PACG). However, these studies may be influenced by bias. We explored the potential causal relationship between host susceptibility to COVID-19 and its severity, and the risk for developing PACG.

Methods: Summary statistics for COVID-19 susceptibility and severity were obtained from the COVID-19 Host Genetics Initiative and utilized as exposure data. Single nucleotide polymorphisms linked to PACG were sourced from the FinnGen project and the VA Million Veteran Program as outcomes. We employed the inverse-variance weighted (IVW) method to investigate the causal relationships between COVID-19 and PACG. A thorough sensitivity analysis was performed to assess the robustness of the identified associations.

Results: Hospitalized COVID-19 showed a significant association with an increased risk for PACG, both in the FinnGen project (odds ratio [OR] = 1.22; 95% confidence interval [CI] = 1.07-1.40; p = 0.003) and the VA Million Veteran Program (OR = 1.08; 95% CI = 1.01-1.16; p = 0.021). Confirmed very severe respiratory COVID-19 was also significantly linked to PACG risk in the FinnGen sample (OR = 1.15; 95% CI = 1.04-1.27; p = 0.006). However, no such association was found in COVID-19 susceptibility in either PACG sample.

Conclusion: Our findings suggest a potential link between severe COVID-19 and increased risk for PACG. This underscores the importance of early screening and proper management of glaucoma in individuals with severe COVID-19.

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COVID-19易感性和严重程度与原发性闭角型青光眼的关系

目的：观察性研究表明，2019冠状病毒病（COVID-19）与原发性闭角型青光眼（PACG）风险增加之间存在联系。然而，这些研究可能受到偏见的影响。我们探讨了宿主对COVID-19易感性及其严重程度与发生PACG风险之间的潜在因果关系。方法：从COVID-19宿主遗传计划中获取COVID-19易感性和严重程度的汇总统计数据，并作为暴露数据。与PACG相关的单核苷酸多态性来源于FinnGen项目和VA百万退伍军人计划。我们采用反方差加权（IVW）方法研究COVID-19与PACG之间的因果关系。进行了彻底的敏感性分析，以评估确定的关联的稳健性。结果：在FinnGen项目中，住院的COVID-19与PACG风险增加显著相关(优势比[OR] = 1.22；95%置信区间[CI] = 1.07-1.40；p = 0.003)和退伍军人事务部百万退伍军人计划(OR = 1.08；95% ci = 1.01-1.16；P = 0.021)。在FinnGen样本中，确诊的非常严重呼吸道COVID-19也与PACG风险显著相关(OR = 1.15；95% ci = 1.04-1.27；P = 0.006)。然而，在两个PACG样本中均未发现COVID-19易感性存在这种关联。结论：我们的研究结果表明，严重的COVID-19与PACG风险增加之间存在潜在联系。这强调了早期筛查和适当管理严重COVID-19患者青光眼的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic epidemiology 医学-眼科学

CiteScore

3.70

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.