Impact of myocardial revascularization surgery on the plasma metabolome.

Abstract

Introduction: Myocardial revascularization (MR) is recommended in acute myocardial infarction. Understanding the physiological disturbances caused by MR may be pertinent for future therapeutic strategies in the postoperative period.

Objectives: This study aims to analyze the MR impact on plasma metabolites and investigate potential correlations between them with routinely measured biochemical and clinical parameters in MR, and with the cardiopulmonary bypass time (CPB).

Methods: Twenty-five patients had plasma samples collected before and after MR for metabolomic analysis, performed by liquid chromatography coupled with high-resolution mass spectrometry.

Results: One hundred eleven ions showed statistically significant differences due to MR and thirteen were identified. Only Pregnenolone Sulfate had its abundance in plasma decreased due to MR. Hydrocortisone succinate, Cortisone, and Corticosterone increased in response to the glucocorticoids administered during surgery. LysoPS 16:1, LysoPC 14:0, Phenylvaleric acid, 13-Hydroxyoctadecadienoic acid, N-Linoleoyl Glutamine, and N-Myristoyl Methionine, along with the significant increase in the white blood cell count are associated with inflammation processes, possibly caused by MR. Furthermore, Pregnenolone sulfate, Pentosidine, Phenylvaleric acid, and N-Myristoyl Methionine were correlated with biochemical/clinical parameters and CPB.

Conclusion: These results open new horizons in the interpretation of physiological disturbances caused by MR, as well as provide support for future studies. The scientific community is invited to build upon the outcomes obtained to confirm the associations suggested in this study, advancing the realm of metabolomics and MR.