Von Willebrand Factor Multimers in Aortic Stenosis Surgery: Dynamics and Disease Correlation.

IF 2.8 2区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of atherosclerosis and thrombosis Pub Date : 2025-08-08 DOI:10.5551/jat.65800

Shuji Tachioka, Hideaki Kanda, Munekazu Yamakuchi, Sadayuki Higashi, Misako Suzuki, Drew N Maywar, Kenji Toyokawa, Kosuke Mukaihara, Kazuhisa Matsumoto, Hisanori Horiuchi, Teruto Hashiguchi, Yoshiharu Soga

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引用次数: 0

Abstract

Aim: The preoperative to early remote postoperative von Willebrand factor (VWF) large multimer index (LMI) in patients with aortic stenosis (AS) remains unclear. Assessment of LMI changes may be better understood if other valvular diseases are integrated. However, this association requires further investigation.

Methods: A quantitative time-course assessment of the VWF, including LMI, was performed in 23 patients with AS who underwent aortic valve replacement. The proposed total valve score was used to study the correlation between the LMI and valvular diseases, including diseases other than AS.

Results: The postoperative VWF LMI was significantly higher; this increase was sustained across nine measurements up to one year postoperatively. The total valve score showed a moderate negative correlation with the VWF LMI (Spearman correlation coefficient r_s = -0.5483, p = 0.0068), demonstrating a stronger negative correlation and a lower p-value than the peak flow velocity and mean pressure gradient.

Conclusions: Improved VWF LMI was maintained one year after AS surgery and correlated better with echocardiographic severity when considering other valvular diseases than AS severity alone. VWF LMI may indicate overall cardiac shear stress and treatment effectiveness in early remote stages.

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主动脉狭窄手术中的血管性血友病因子多聚体：动力学和疾病相关性。

目的：主动脉瓣狭窄（aortic stenosis， AS）患者术前到术后早期的血管性血友病因子（VWF）大倍数指数（LMI）尚不清楚。如果结合其他瓣膜疾病，对LMI变化的评估可能会更好。然而，这种联系需要进一步调查。方法：对23例接受主动脉瓣置换术的AS患者进行VWF（包括LMI）的定量时间过程评估。提出的瓣膜总评分用于研究LMI与瓣膜疾病（包括AS以外的疾病）的相关性。结果：术后VWF LMI明显增高；这种增加在9项测量中持续到术后1年。阀总评分与VWF LMI呈中度负相关（Spearman相关系数rs = -0.5483, p = 0.0068），比峰值流速和平均压力梯度负相关更强，p值更低。结论：改善的VWF LMI在AS术后维持一年，在考虑其他瓣膜疾病时与超声心动图严重程度的相关性优于单独的AS严重程度。VWF LMI可能反映心脏整体剪应力和早期治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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