Diagnostic values of the monocyte to hemoglobin ratio and neutrophil-lymphocyte ratio to albumin ratio in non-small cell lung cancer.

IF 1.1 4区医学 Q4 ONCOLOGY

Indian journal of cancer Pub Date : 2025-04-01 Epub Date: 2025-08-08 DOI:10.4103/ijc.ijc_241_23

Si-Ting Zhao, Fen-Hong Qian

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引用次数: 0

Abstract

Objective: To evaluate the diagnostic utilities of monocyte to hemoglobin ratio (MHR) and neutrophil-lymphocyte ratio to albumin ratio (NLRAR) in the detection of non-small cell lung cancer (NSCLC).

Methods: We retrospectively collected and analyzed the clinical and laboratory data, including 196 NSCLC cases and 204 controls.

Results: The area under the curve (AUC) for 95% confidence interval (95% CI) of MHR and NLRAR in the diagnosis of NSCLC were found to be 0.822 (0.781-0.864) and 0.712 (0.662-0.762), respectively. The combined use of MHR, NLRAR, and carcinoma embryonic antigen (CEA) exhibited higher diagnostic sensitivity (AUC: 0.855; 95% CI: 0.818-0.892; sensitivity: 70.4%; specificity: 89.2%) than the use of individual markers or two markers combined. MHR was a potential biomarker to detect early-stage NSCLC.

Conclusions: MHR and NLRAR are effective auxiliary biomarkers to predict the presence of NSCLC. When these markers are combined with CEA the diagnostic effects will further improve.

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单核细胞与血红蛋白比值和中性淋巴细胞与白蛋白比值在非小细胞肺癌中的诊断价值。

目的：探讨单核细胞与血红蛋白比值（MHR）和中性淋巴细胞与白蛋白比值（NLRAR）对非小细胞肺癌（NSCLC）的诊断价值。方法：回顾性收集和分析196例非小细胞肺癌病例和204例对照患者的临床和实验室资料。结果：MHR和NLRAR诊断NSCLC的95%可信区间（95% CI）曲线下面积（AUC）分别为0.822（0.781-0.864）和0.712（0.662-0.762）。联合使用MHR、NLRAR和癌胚抗原（CEA）具有较高的诊断敏感性(AUC: 0.855；95% ci: 0.818-0.892；灵敏度:70.4%;特异性：89.2%)比使用单个标记或两种标记联合。MHR是检测早期非小细胞肺癌的潜在生物标志物。结论：MHR和NLRAR是预测非小细胞肺癌存在的有效辅助生物标志物。当这些标志物与CEA联合使用时，诊断效果将进一步提高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian journal of cancer Medicine-Oncology

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Indian Journal of Cancer (ISSN 0019-509X), the show window of the progress of ontological sciences in India, was established in 1963. Indian Journal of Cancer is the first and only periodical serving the needs of all the specialties of oncology in India.