Assessment of immunological and hematological parameters in Blastocystis species-infected chronic leukemic patients.

IF 4 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gut Pathogens Pub Date : 2025-08-11 DOI:10.1186/s13099-025-00733-0

Heba Elhadad, Bassam Mohamed Abdel-Fattah, Sally A M Saleh, Moustafa Abo El-Hoda, Hend El-Taweel

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引用次数: 0

Abstract

Aim: Blastocystis spp. is a common intestinal protozoan with controversial pathogenicity. It is frequently associated with gastrointestinal (GIT) disturbances and is particularly prevalent among immunocompromised individuals. This study aimed to assess the prevalence of Blastocystis spp. infection and its association with immunological and hematological parameters among chronic leukemic patients.

Methods: Stool and blood samples were collected from 100 chronic leukemic patients. Microscopic examination and a coproantigen assay were performed for the detection of Blastocystis spp., along with assessment of anti-Blastocystis fecal IgA and serum IgG antibodies. CD4 T cells and the serum level of IL-8 were also measured.

Results: The overall Blastocystis spp. infection rate was 60%, determined through combined microscopy and/or coproantigen detection. Among infected patients, anti-Blastocystis IgA was positive in only three patients and IgG in 18 patients, with no statistically significant association between Blastocystis spp. infection and detection of antibodies. Infection was significantly associated with elevated IL-8 levels and WBC count. There was no statistically significant association between the presence of gastrointestinal symptoms and the levels of anti-Blastocystis IgG or IgA, IL-8, or CD4 count in Blastocystis spp.-infected patients.

Conclusion: Our study reveals a high prevalence of Blastocystis spp. infection among chronic leukemic patients and identifies a significant association between infection and elevated IL-8 levels.

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囊虫感染慢性白血病患者免疫学和血液学指标的评价。

目的：囊虫是一种常见的肠道原生动物，其致病性存在争议。它通常与胃肠道（GIT）紊乱有关，在免疫功能低下的个体中尤为普遍。本研究旨在评估慢性白血病患者囊虫感染的患病率及其与免疫和血液学参数的关系。方法：对100例慢性白血病患者进行粪便和血液采集。显微镜检查和粪原抗原检测囊虫属，并评估抗囊虫粪便IgA和血清IgG抗体。同时检测CD4 T细胞和血清IL-8水平。结果：综合镜检和/或粪原抗原检测，囊虫感染率为60%。在感染患者中，抗囊虫IgA阳性仅3例，IgG阳性18例，囊虫感染与抗体检测无统计学意义。感染与白细胞介素-8水平升高和白细胞计数显著相关。在囊虫感染患者中，胃肠道症状的存在与抗囊虫IgG或IgA、IL-8或CD4计数水平无统计学意义。结论：我们的研究揭示了慢性白血病患者中囊虫感染的高发率，并确定了感染与IL-8水平升高之间的显著关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gut Pathogens GASTROENTEROLOGY & HEPATOLOGY-MICROBIOLOGY

CiteScore

7.70

自引率

2.40%

发文量

期刊介绍： Gut Pathogens is a fast publishing, inclusive and prominent international journal which recognizes the need for a publishing platform uniquely tailored to reflect the full breadth of research in the biology and medicine of pathogens, commensals and functional microbiota of the gut. The journal publishes basic, clinical and cutting-edge research on all aspects of the above mentioned organisms including probiotic bacteria and yeasts and their products. The scope also covers the related ecology, molecular genetics, physiology and epidemiology of these microbes. The journal actively invites timely reports on the novel aspects of genomics, metagenomics, microbiota profiling and systems biology. Gut Pathogens will also consider, at the discretion of the editors, descriptive studies identifying a new genome sequence of a gut microbe or a series of related microbes (such as those obtained from new hosts, niches, settings, outbreaks and epidemics) and those obtained from single or multiple hosts at one or different time points (chronological evolution).