{"title":"A bibliometric analysis of the immune system and cognitive impairment: trends from 1985 to 2024.","authors":"Beibei Zou, Jinxi Xiang, Muhua Zhang, Jing Huang, Chao Feng","doi":"10.3389/fnagi.2025.1587575","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment is closely linked to immune system dysfunction, with increasing research interest in the underlying mechanisms and potential therapeutic targets. Bibliometric analysis provides a comprehensive approach to understanding research trends, influential contributions, and emerging topics in this interdisciplinary field.</p><p><strong>Methods: </strong>This study conducted a bibliometric analysis of publications related to the immune system and cognitive impairment from 1985 to 2024, retrieved from the Web of Science Core Collection. CiteSpace (6.4. R1), VOSviewer (1.6.20), and R-bibliometrix (R 4.3.0) were employed to analyze publication trends, co-authorship networks, keyword clustering, and co-citation patterns. Key metrics, including the H-index, G-index, and M-index, were computed to assess academic influence.</p><p><strong>Results: </strong>A total of 3,737 publications were analyzed, revealing a significant increase in research output since 2021. The United States and China emerged as leading contributors, with a robust presence of collaborative networks. Keyword and co-citation analysis identified core research themes, including neuroinflammation, microglia activation, gut microbiota, TREM2-mediated immune responses, and inflammasomes. Emerging topics such as the gut-brain axis, metabolic syndromes, and immune regulation in neurodegenerative diseases have gained prominence in recent years. Highly cited papers highlighted the role of immune dysregulation in Alzheimer's disease, multiple sclerosis, and HIV-associated neurocognitive disorders.</p><p><strong>Conclusion: </strong>This bibliometric analysis provides a comprehensive overview of research trends in immune-related cognitive impairment. The findings indicate an increasing focus on neuroinflammatory mechanisms, immune cell interactions, and novel immunotherapeutic strategies. Future research is expected to further explore the gut-immune-brain axis and precision medicine approaches in managing cognitive disorders. These findings may facilitate early detection strategies and novel interventions targeting immune-cognitive interactions, such as gut-brain axis modulation.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1587575"},"PeriodicalIF":4.5000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336137/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Aging Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnagi.2025.1587575","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Cognitive impairment is closely linked to immune system dysfunction, with increasing research interest in the underlying mechanisms and potential therapeutic targets. Bibliometric analysis provides a comprehensive approach to understanding research trends, influential contributions, and emerging topics in this interdisciplinary field.
Methods: This study conducted a bibliometric analysis of publications related to the immune system and cognitive impairment from 1985 to 2024, retrieved from the Web of Science Core Collection. CiteSpace (6.4. R1), VOSviewer (1.6.20), and R-bibliometrix (R 4.3.0) were employed to analyze publication trends, co-authorship networks, keyword clustering, and co-citation patterns. Key metrics, including the H-index, G-index, and M-index, were computed to assess academic influence.
Results: A total of 3,737 publications were analyzed, revealing a significant increase in research output since 2021. The United States and China emerged as leading contributors, with a robust presence of collaborative networks. Keyword and co-citation analysis identified core research themes, including neuroinflammation, microglia activation, gut microbiota, TREM2-mediated immune responses, and inflammasomes. Emerging topics such as the gut-brain axis, metabolic syndromes, and immune regulation in neurodegenerative diseases have gained prominence in recent years. Highly cited papers highlighted the role of immune dysregulation in Alzheimer's disease, multiple sclerosis, and HIV-associated neurocognitive disorders.
Conclusion: This bibliometric analysis provides a comprehensive overview of research trends in immune-related cognitive impairment. The findings indicate an increasing focus on neuroinflammatory mechanisms, immune cell interactions, and novel immunotherapeutic strategies. Future research is expected to further explore the gut-immune-brain axis and precision medicine approaches in managing cognitive disorders. These findings may facilitate early detection strategies and novel interventions targeting immune-cognitive interactions, such as gut-brain axis modulation.
期刊介绍：
Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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