Synergistic effect of piperine on curcumin in cisplatin-induced nephrotoxicity through DNA fragmentation and cytokines gene expressions.

IF 1.9 4区医学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Drug and Chemical Toxicology Pub Date : 2025-08-11 DOI:10.1080/01480545.2025.2543421

Sohail Hussain, Mohammad Ashafaq, Saeed Alshahrani, Marwa Qadri, Amani Khardali, Wedad Mawkili, Dalin A Hassan, Mohammad Intakhab Alam, Yosif Almoshari, Manal Mohammed Elhassan Taha, Rahimullah Siddiqui

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引用次数: 0

Abstract

Cisplatin (Cis) is an anticancer drug commonly used to treat solid tumors. However, because of its nephrotoxicity, its use is limited. Our goal was to evaluate the effects of curcumin (Cur) and piperine (Pip) administered separately versus combined on Cis-induced nephrotoxicity in rats. Significant adverse physiological, biochemical, and histological effects, such as decreased body weight, renal damage indices in serum and kidney tissue of indicated nephrotoxicity are caused by Cis (6 mg/kg, intraperitoneally i.p.). Cis also altered histological changes, DNA damage, renal oxidative stress, and several pro-inflammatory cytokines. By reducing proinflammatory and apoptotic mediators and enhancing antioxidant competence in the renal tissues of Cis-treated rats by supplementation with either Cur (200 mg/kg o.p.) or Pip (20 mg/kg o.p.) administered singly for 12 days, notably reduced the negative renal effects of Cis. In all the parameters, the ameliorative effect was greatly increased when Cur and Pip were administered together.

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胡椒碱通过DNA片段化和细胞因子基因表达对姜黄素在顺铂所致肾毒性中的协同作用。

顺铂（Cis）是一种常用的治疗实体瘤的抗癌药物。然而，由于其肾毒性，其使用受到限制。我们的目的是评估姜黄素（Cur）和胡椒碱（Pip）单独给药与联合给药对顺式肾毒性大鼠的影响。顺式脂肪酸（6 mg/kg，腹腔灌胃）可引起显著的生理、生化和组织学不良反应，如体重下降、血清和肾组织肾损伤指标显示肾毒性。顺式还改变了组织学变化、DNA损伤、肾脏氧化应激和几种促炎细胞因子。通过在Cis处理大鼠肾脏组织中单独添加Cur （200 mg/kg o.p.）或Pip (20 mg/kg o.p.) 12天，减少促炎和凋亡介质，增强抗氧化能力，显著降低Cis对肾脏的负面影响。在所有参数中，Cur与Pip合用可显著提高改善效果。

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来源期刊

Drug and Chemical Toxicology 医学-毒理学

CiteScore

6.00

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Drug and Chemical Toxicology publishes full-length research papers, review articles and short communications that encompass a broad spectrum of toxicological data surrounding risk assessment and harmful exposure. Manuscripts are considered according to their relevance to the journal. Topics include both descriptive and mechanics research that illustrates the risk assessment implications of exposure to toxic agents. Examples of suitable topics include toxicological studies, which are structural examinations on the effects of dose, metabolism, and statistical or mechanism-based approaches to risk assessment. New findings and methods, along with safety evaluations, are also acceptable. Special issues may be reserved to publish symposium summaries, reviews in toxicology, and overviews of the practical interpretation and application of toxicological data.