The predictive value of serum mRNA-RGS10 for the severity and prognosis of acute pancreatitis

IF 2.9 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2025-08-09 DOI:10.1016/j.cca.2025.120531

Jie Li , Hanhui Li , Xiaoping Tan , Jun Zhang , Shengqi Du , Yueyue Lu , Qing Zhang

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引用次数: 0

Abstract

Objectives

The study investigates serum RGS10 expression in acute pancreatitis (AP) patients and its prognostic value.

Methods

Serum samples and clinical data were collected from 104 AP patients and 34 healthy controls (HC). Whole transcriptome sequencing was performed on serum samples from three randomly selected individuals per group.

Results

Serum RGS10 levels were significantly higher in the moderately severe acute pancreatitis (MSAP) group compared to the mild acute pancreatitis (MAP) and HC (P < 0.01). RGS10 expression was positively correlated with BISAP score, CTSI, INR, PCT, BUN, and Cr. Univariate and multivariate regression analyses identified RGS10, hydrothorax, and Ca²⁺ as independent risk factors for MSAP. RGS10 demonstrated the highest predictive accuracy for MSAP, with an accuracy of 80.0 %, sensitivity of 78.0 %, specificity of 74.1 %. Combining these indicators enhanced the predictive efficacy, achieving an accuracy of 91.2 %, sensitivity of 92.7 %, specificity of 76.3 %. Follow-up data indicated that RGS10, Cr, D-dimer, CTSI, PTAR, PLR, BUN, PT, INR, and disease severity were risk factors for recurrence AP.

Conclusions

RGS10 may serve as a novel biomarker for AP severity and recurrence risk.

查看原文本刊更多论文

血清mRNA-RGS10对急性胰腺炎严重程度及预后的预测价值。

目的：探讨急性胰腺炎（AP）患者血清RGS10的表达及其预后价值。方法：收集104例AP患者和34例健康对照者的血清和临床资料。每组随机选取3名个体的血清样本进行全转录组测序。结果：中重度急性胰腺炎（MSAP）组血清RGS10水平明显高于轻度急性胰腺炎（MAP）和HC （P 2+）作为MSAP的独立危险因素。RGS10对MSAP的预测准确率最高，准确率为80.0 %，灵敏度为78.0 %，特异性为74.1 %。结合这些指标可提高预测效果，准确率为91.2 %，灵敏度为92.7 %，特异性为76.3 %。随访数据显示，RGS10、Cr、d -二聚体、CTSI、PTAR、PLR、BUN、PT、INR和疾病严重程度是AP复发的危险因素。结论：RGS10可能作为AP严重程度和复发风险的新型生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.