Deletion of rgaS reduces virulence in a mouse model of Clostridioides difficile infection

IF 2.6 3区生物学 Q3 MICROBIOLOGY

Anaerobe Pub Date : 2025-08-09 DOI:10.1016/j.anaerobe.2025.102988

Terry W. Bilverstone , Morgan E. Simpson , Nicholas Hagspiel , William A. Petri , Sarah A. Kuehne , Nigel P. Minton

引用次数: 0

Abstract

Two-component system signalling is involved in several processes relevant to Clostridioides difficile virulence. We demonstrate that deletion of the orphan histidine kinase rgaS (R20291_0503), reduces detectable toxin in the supernatant of R20291 and impairs virulence in a mouse model of infection. These data suggest that RgaS regulates virulence capabilities in hypervirulent C. difficile.

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在艰难梭菌感染小鼠模型中，缺失rgaS可降低毒力。

双组分系统信号参与了艰难梭菌毒力相关的几个过程。我们证明，缺失孤儿组氨酸激酶rgaS (R20291_0503)，减少了R20291上清中可检测到的毒素，并削弱了小鼠感染模型的毒力。这些数据表明，RgaS调节了高毒力艰难梭菌的毒力能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.