Therapeutic Effects of Electroencephalogram-Based Bioelectric Stimulation on Cognitive-Behavioural Outcomes in Children With Dual Diagnosis of Autism Spectrum Disorder and Intellectual Disability.

IF 1.6 4区医学 Q4 NEUROSCIENCES

Actas espanolas de psiquiatria Pub Date : 2025-08-01 DOI:10.62641/aep.v53i4.1975

Jiufang He, Yiping Shi, Xike Wang

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Abstract

Objectives: This investigation evaluates the interventional effects of electroencephalogram-based bioelectric stimulation (EBBS) on intellectual development and behavioural symptoms in children with autism spectrum disorder (ASD) and comorbid intellectual disability (ID).

Methods: By utilising a retrospective cohort design, the research team analysed 310 clinically diagnosed cases of ASD and ID that were stratified into two intervention groups: a conventional group (n = 163) receiving conventional interventions (behavioural applied behaviour analysis (ABA) therapy and structured instruction) and an observation group (n = 147) receiving the same behavioural interventions combined with EBBS. Before and following the treatment, the childhood autism rating scale (CARS), Montreal cognitive assessment (MoCA), developmental age and developmental quotient (DQ) and infants-junior middle school students' social-life abilities scale (S-M) were employed to assess symptom alleviation, cognitive capabilities and quality of life. The levels of serum 25-hydroxyvitamin D [25(OH)D], folic acid (FA) and brain-derived neurotrophic factor (BDNF) were also measured.

Results: After treatment, the observation group showed significantly lower CARS scores; increased post-treatment serum levels of 25(OH)D, FA and BDNF; and improved MoCA scores than the conventional group (p < 0.05). Regarding developmental age and DQ, the observation group demonstrated significant improvements in the subscales of fine motor skills, language, adaptive ability and social interaction after intervention (p < 0.05). Additionally, the S-M total scores and all quality-of-life indicators were superior in the observation group (p < 0.05).

Conclusion: EBBS has the potential to collaboratively enhance the cognitive function, behavioural symptoms and quality of life of children with comorbid ASD and ID.

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基于脑电图的生物电刺激对自闭症谱系障碍和智力障碍双重诊断儿童认知行为结局的影响。

目的：探讨基于脑电图的生物电刺激（EBBS）对自闭症谱系障碍（ASD）和共病性智力残疾（ID）患儿智力发育和行为症状的干预作用。方法：通过回顾性队列设计，研究小组分析了310例临床诊断的ASD和ID病例，将其分为两组：常规组（n = 163）接受常规干预（行为应用行为分析（ABA）治疗和结构化指导），观察组（n = 147）接受相同的行为干预结合EBBS。治疗前后分别采用儿童自闭症评定量表（CARS）、蒙特利尔认知评估量表（MoCA）、发育年龄与发展商量表（DQ）和婴幼儿-初中生社会生活能力量表（S-M）评估症状缓解程度、认知能力和生活质量。测定血清25-羟基维生素D [25(OH)D]、叶酸（FA）和脑源性神经营养因子（BDNF）水平。结果：治疗后，观察组患者的CARS评分显著降低；治疗后血清25(OH)D、FA和BDNF水平升高；MoCA评分明显高于常规组（p < 0.05）。在发育年龄和DQ方面，观察组干预后在精细运动技能、语言能力、适应能力和社会交往能力各分量表上均有显著改善（p < 0.05）。观察组患者S-M总分及各项生活质量指标均优于对照组（p < 0.05）。结论：EBBS有可能协同改善ASD和ID合并症患儿的认知功能、行为症状和生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Actas espanolas de psiquiatria 医学-精神病学

CiteScore

1.70

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： Actas Españolas de Psiquiatría publicará de manera preferente trabajos relacionados con investigación clínica en el área de la Psiquiatría, la Psicología Clínica y la Salud Mental.