A unique p52 NF-κB–ETS1 interaction ushers in a new paradigm of germinal center responses

IF 27.6 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-08-12 DOI:10.1038/s41590-025-02246-z

Lee Ann Garrett-Sinha, Satrajit Sinha

引用次数: 0

Abstract

A complex of the NF-κB family member p52 and the transcription factor ETS1 is required for B cell germinal center responses to T cell-dependent immunization and for IgE-dependent allergic responses.

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一个独特的p52 NF -κB-ETS1相互作用引入了生发中心反应的新范式

NF-κB家族成员p52和转录因子ETS1的复合体是B细胞生发中心对T细胞依赖性免疫反应和ige依赖性过敏反应所必需的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.