Bone-formation-related markers in osteonecrosis of the jaws and their correlation with radiographic findings.

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Oral and maxillofacial surgery Pub Date : 2025-08-11 DOI:10.1007/s10006-025-01439-y

Riéli Elis Schulz, Sandro Wopereis, Juliana Lucena Schussel, Laurindo Moacir Sassi, Aira Maria Bonfim Santos, Liliane Janete Grando, Rogério Oliveira Gondak, Gustavo Davi Rabelo

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Abstract

Purpose: To evaluate serum levels of the bone-formation-related markers sclerostin and alkaline phosphatase (ALP) in patients with medication-related osteonecrosis of the jaw (MRONJ) and osteoradionecrosis (ORN), and to identify a correlation with radiographic findings.

Methods: A cross-sectional study was conducted with osteonecrosis patients [MRONJ (n = 11); ORN (n = 21)] compared with individuals without osteometabolic diseases (control group, CG n = 27). Serum levels of sclerostin (pg/ml) and ALP (U/L) were evaluated. Gray-level pixel intensity (mean-Mgv and standard deviation-SDgv), fractal dimension (FD), and lacunarity (Lac) in the necrotic site (N), at the perinecrotic bone (PB), and in the non-lesional-bone site (CB) were assessed.

Results: Higher sclerostin levels were observed in ORN (90, p = 0.04) and MRONJ (133, p < 0.01) vs. CG (45). ALP differed (p < 0.01) between MRONJ (60.2) and CG (79.3). All radiographic parameters revealed significant differences among the 3 sites (p < 0.05). A multivariate analysis showed an association of sclerostin with Mgv at N (p = 0.002) and Lac (p < 0.004) at CB, and an association of ALP with Mgv at N (p < 0.01), SDgv at PB (p < 0.01), and with sclerostin (p < 0.01).

Conclusions: Serum sclerostin levels were higher in patients with osteonecrosis. ALP levels were lower in MRONJ patients than in CG. Both proteins were associated with each other and with radiographic findings.

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颌骨骨坏死中骨形成相关标记物及其与影像学表现的相关性。

目的：评价药物相关性颌骨骨坏死（MRONJ）和放射性骨坏死（ORN）患者血清中骨形成相关标志物硬化蛋白（sclerostin）和碱性磷酸酶（ALP）的水平，并确定其与影像学表现的相关性。方法：对骨坏死患者进行横断面研究[MRONJ] (n = 11)；（n = 21）]与无骨代谢疾病个体（对照组，CG n = 27）比较。测定血清硬化素（pg/ml）和ALP （U/L）。评估坏死部位(N)、坏死性骨（PB）和非病变骨（CB）的灰度像素强度（mean-Mgv和标准差- sdgv）、分形维数（FD）和腔隙度（Lac）。结果：ORN（90例，p = 0.04）和MRONJ（133例，p）患者血清硬化蛋白水平较高。MRONJ患者ALP水平低于CG患者。这两种蛋白相互关联，并与影像学表现相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Oral and maxillofacial surgery

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