Evaluation of Reactogenicity and Neutralizing Antibody Responses 6 Months Post-Vaccination with Monovalent COVID-19 Vaccine.

IF 2.9 Q2 INFECTIOUS DISEASES

Infection and Chemotherapy Pub Date : 2025-09-01 Epub Date: 2025-07-18 DOI:10.3947/ic.2025.0027

So Yun Lim, Hye Hee Cha, Ji Yeon Kim, Ji-Soo Kwon, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Ho Choi, Sang-Oh Lee, Yang Soo Kim, Sung-Han Kim

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Abstract

The association between reactogenicity and long-term immunogenicity after coronavirus disease 2019 (COVID-19) vaccination remains unclear. This study investigated whether adverse reactions to ChAdOx1 nCoV-19 or BNT162b2 vaccines correlate with neutralizing antibody responses in severe acute respiratory syndrome coronavirus 2 infection-naïve healthcare workers. Blood samples were collected at three time points to measure neutralizing antibodies. Among 123 participants (ChAdOx1 nCoV-19, n=88; BNT162b2, n=35), local and systemic reactions were not significantly associated with antibody responses at six months post-vaccination for either vaccine type. No significant interactions between symptoms, time points, or age were observed. These findings suggest that adverse reactions might not predict long-term neutralizing antibody levels following COVID-19 vaccination.

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单价COVID-19疫苗接种6个月后反应性和中和抗体反应的评价

2019冠状病毒病（COVID-19）疫苗接种后的反应原性与长期免疫原性之间的关系尚不清楚。本研究调查了ChAdOx1 nCoV-19或BNT162b2疫苗的不良反应是否与严重急性呼吸综合征冠状病毒2 infection-naïve医护人员的中和抗体反应相关。在三个时间点采集血样，测量中和抗体。123名受试者(ChAdOx1 nCoV-19, n = 88；BNT162b2, n = 35)，两种疫苗接种后6个月的局部和全身反应与抗体反应无显著相关。未观察到症状、时间点或年龄之间的显著相互作用。这些发现表明，不良反应可能无法预测COVID-19疫苗接种后的长期中和抗体水平。

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