{"title":"Association of vitamin D receptor gene polymorphisms in gastrointestinal cancer: A systematic review and meta-analysis.","authors":"Hongyu Wang, Yawen Yang, Juan Du","doi":"10.1016/j.prp.2025.156155","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal cancers (GICs), encompassing malignancies of the esophagus, stomach, and colorectal regions, are among the most prevalent cancers worldwide. Given the inconsistent and heterogeneous findings across studies, this meta-analysis aims to comprehensively assess the association between vitamin D receptor (VDR) gene polymorphisms and the risk of GICs.</p><p><strong>Methods: </strong>A systematic search was conducted in MEDLINE, Web of Science, Scopus, and Embase to identify relevant studies investigating the association between VDR polymorphisms and GIC risk. After removing duplicates, studies were screened based on predefined inclusion and exclusion criteria. Data analysis was performed using Comprehensive Meta-Analysis software (version 2). Publication bias was evaluated using Egger's test, and study heterogeneity was assessed using the I² statistic. Pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated.</p><p><strong>Results: </strong>A total of 51 studies were included in the meta-analysis. Significant associations were found between gastric cancer and the FokI polymorphism (ff vs. FF: OR = 1.58; FF+Ff vs. ff: OR = 0.52), as well as the TaqI polymorphism (tt vs. TT: OR = 1.70). For colorectal cancer (CRC), the BsmI variant showed consistent associations in the recessive, heterozygous, and allelic models, even after excluding studies not in Hardy-Weinberg equilibrium. No significant associations were observed for Cdx2 or in relation to esophageal cancer. Subgroup and meta-regression analyses revealed age- and region-specific effects.</p><p><strong>Conclusion: </strong>VDR gene polymorphisms, particularly FokI and TaqI, are significantly associated with gastric cancer risk, while BsmI is linked to increased susceptibility to CRC. No associations were observed for esophageal cancer. These results support the potential role of genetic variants in gastrointestinal carcinogenesis and warrant further validation in diverse populations.</p>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"274 ","pages":"156155"},"PeriodicalIF":3.2000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathology, research and practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.prp.2025.156155","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/5 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Gastrointestinal cancers (GICs), encompassing malignancies of the esophagus, stomach, and colorectal regions, are among the most prevalent cancers worldwide. Given the inconsistent and heterogeneous findings across studies, this meta-analysis aims to comprehensively assess the association between vitamin D receptor (VDR) gene polymorphisms and the risk of GICs.
Methods: A systematic search was conducted in MEDLINE, Web of Science, Scopus, and Embase to identify relevant studies investigating the association between VDR polymorphisms and GIC risk. After removing duplicates, studies were screened based on predefined inclusion and exclusion criteria. Data analysis was performed using Comprehensive Meta-Analysis software (version 2). Publication bias was evaluated using Egger's test, and study heterogeneity was assessed using the I² statistic. Pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated.
Results: A total of 51 studies were included in the meta-analysis. Significant associations were found between gastric cancer and the FokI polymorphism (ff vs. FF: OR = 1.58; FF+Ff vs. ff: OR = 0.52), as well as the TaqI polymorphism (tt vs. TT: OR = 1.70). For colorectal cancer (CRC), the BsmI variant showed consistent associations in the recessive, heterozygous, and allelic models, even after excluding studies not in Hardy-Weinberg equilibrium. No significant associations were observed for Cdx2 or in relation to esophageal cancer. Subgroup and meta-regression analyses revealed age- and region-specific effects.
Conclusion: VDR gene polymorphisms, particularly FokI and TaqI, are significantly associated with gastric cancer risk, while BsmI is linked to increased susceptibility to CRC. No associations were observed for esophageal cancer. These results support the potential role of genetic variants in gastrointestinal carcinogenesis and warrant further validation in diverse populations.
背景：胃肠道肿瘤（gic）包括食道、胃和结直肠的恶性肿瘤，是世界上最常见的癌症之一。鉴于各研究结果的不一致性和异质性，本荟萃分析旨在全面评估维生素D受体（VDR）基因多态性与gic风险之间的关系。方法：系统检索MEDLINE、Web of Science、Scopus和Embase，寻找VDR多态性与GIC风险之间的相关研究。去除重复项后，根据预定义的纳入和排除标准筛选研究。采用综合meta分析软件（version 2）进行数据分析。采用Egger检验评价发表偏倚，采用I²统计量评价研究异质性。计算了合并优势比（ORs）和95% %置信区间（ci）。结果：meta分析共纳入51项研究。胃癌与FokI多态性存在显著相关性(ff vs. ff: OR = 1.58；FF+ FF vs. FF: OR = 0.52)以及TaqI多态性（tt vs. tt: OR = 1.70）。对于结直肠癌（CRC），即使在排除了不符合Hardy-Weinberg平衡的研究后，BsmI变异在隐性、杂合和等位基因模型中也显示出一致的相关性。未观察到Cdx2或与食管癌相关的显著相关性。亚组和元回归分析揭示了年龄和地区特异性影响。结论：VDR基因多态性，特别是FokI和TaqI与胃癌风险显著相关，而BsmI与CRC易感性增加相关。没有观察到与食管癌相关。这些结果支持遗传变异在胃肠道癌变中的潜在作用，并需要在不同人群中进一步验证。
期刊介绍：
Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
