Functional Recovery Promotion After Spinal Cord Injury With Astaxanthin Treatment in Preclinical Studies: A Systematic Review and Meta-Analysis.

IF 2.8 Q4 NEUROSCIENCES

Neurology Research International Pub Date : 2025-08-01 eCollection Date: 2025-01-01 DOI:10.1155/nri/9424887

Razieh Hajisoltani, Faeze Sadat Ahmadi Tabatabaei, Michael R Hamblin, Fatemeh Ramezani

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Abstract

Introduction: Due to anti-inflammatory, antioxidant, immune-modulating, and antiaging properties of astaxanthin, it has been used to treat spinal cord injuries (SCIs). In this meta-analysis study, the effects of astaxanthin on SCI in animal models were investigated. Method: Scopus, PubMed, Web of Science, and Google Scholar databases were searched based on keywords related to astaxanthin and SCI. The primary screening of articles based on the title and abstract and the secondary screening based on the full text of the articles according to inclusion and exclusion criteria were performed. After extracting the data, statistical analysis was done using STATA software. A standardized mean difference (SMD) was used to analyze the results of the reported studies. Subgroup analysis and quality control of articles was also performed. Result: The overall results showed that astaxanthin has a strong effect (SMD = 3.34; 95% CI: 1.90 to 4.78; p < 0.001) on improving motor function after SCI especially when administered in multiple doses over consecutive days. Astaxanthin has a strong effect on reducing lipid peroxidation and increasing antioxidants. Treatment with astaxanthin increased the number of spinal cord neurons and spared white matter. Conclusion: Astaxanthin has the potential to be used as an adjuvant in improving motor behavior, and it is suggested to conduct clinical studies on it.

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虾青素治疗促进脊髓损伤后功能恢复的临床前研究：系统回顾和荟萃分析。

由于虾青素的抗炎、抗氧化、免疫调节和抗衰老特性，它已被用于治疗脊髓损伤（sci）。在这项荟萃分析研究中，研究了虾青素对动物模型脊髓损伤的影响。方法：基于虾青素与SCI相关关键词检索Scopus、PubMed、Web of Science、谷歌Scholar等数据库。根据标题和摘要对文章进行初步筛选，根据纳入标准和排除标准对文章全文进行二次筛选。提取数据后，使用STATA软件进行统计分析。采用标准化平均差（SMD）对报道的研究结果进行分析。并进行亚组分析和质量控制。结果：综合结果表明虾青素具有较强的抑菌效果(SMD = 3.34；95% CI: 1.90 ~ 4.78；p < 0.001)对改善脊髓损伤后运动功能的作用，特别是连续多天给药。虾青素对减少脂质过氧化和增加抗氧化剂有很强的作用。虾青素治疗增加了脊髓神经元的数量，并保留了白质。结论：虾青素具有作为辅助药物改善运动行为的潜力，建议开展临床研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology Research International NEUROSCIENCES-

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Neurology Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focusing on diseases of the nervous system, as well as normal neurological functioning. The journal will consider basic, translational, and clinical research, including animal models and clinical trials.