Effect of a Multidisciplinary Clinic on Time to Treatment for Soft Tissue Sarcoma

IF 1.9 3区医学 Q3 ONCOLOGY

Journal of Surgical Oncology Pub Date : 2025-08-11 DOI:10.1002/jso.70061

Britany Hollenquest, Kelsey Montgomery, Adam Lucy, Adam Banks, Vanessa Eulo, Kristy Broman

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Abstract

Background and Objectives

Delay in treatment may be associated with worse outcomes for soft tissue sarcoma, which often requires multidisciplinary management. Our objective was to evaluate the implementation of a sarcoma multidisciplinary clinic (MDC) on time to treatment initiation (TTI) at our tertiary cancer center.

Methods

Patients with localized or metastatic soft tissue sarcoma were seen at our tertiary referral center from November 2021-January 2024 in MDC or usual care (single specialty clinic). Treatment delay was defined as greater than 50 days from initial assessment to first treatment (surgery, radiation, or systemic therapy), compared using chi-squared tests and multivariable logistic regression.

Results

Among 275 patients, 33 were seen in MDC and 242 usual care. Median TTI was 33.0 days (interquartile range (IQR) 18–57). Eighty-two patients (29.8%) had treatment delays, with no difference for MDC (31.1%) versus usual care (15.2%) (p = 0.05) (adjusted odds ratio 0.39, 95% Confidence Interval 0.14–1.06). Patients evaluated in the MDC were more likely to receive multimodal therapy (75.8% vs. 41.7%, p < 0.01) and radiation as their first treatment (54.5% vs. 27.3%, p < 0.01).

Conclusion

Implementation of a MDC did not significantly reduce treatment delay but was associated with increased likelihood of multimodal therapy. Future work should evaluate TTI in cohorts with greater penetrance of MDC care and assess other oncology and patient-centered endpoints.

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多学科临床对软组织肉瘤治疗时间的影响。

背景和目的：软组织肉瘤的延迟治疗可能与较差的预后相关，这通常需要多学科管理。我们的目的是评估我们三级癌症中心肉瘤多学科临床（MDC）按时开始治疗（TTI）的实施情况。方法：局限性或转移性软组织肉瘤患者于2021年11月至2024年1月在我们的三级转诊中心进行MDC或常规护理（单一专科诊所）。治疗延迟定义为从初始评估到首次治疗（手术、放疗或全身治疗）大于50天，使用卡方检验和多变量logistic回归进行比较。结果：275例患者中，33例在MDC就诊，242例在常规护理。中位TTI为33.0天（四分位数间距（IQR） 18-57）。82例患者（29.8%）出现治疗延误，MDC（31.1%）与常规护理（15.2%）无差异（p = 0.05）（调整优势比0.39,95%可信区间0.14-1.06）。在MDC中评估的患者更有可能接受多模式治疗（75.8% vs. 41.7%）。结论：MDC的实施并没有显著减少治疗延迟，但与多模式治疗的可能性增加有关。未来的工作应该评估TTI在MDC护理更高外显率的队列中，并评估其他肿瘤和以患者为中心的终点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Surgical Oncology 医学-外科

CiteScore

4.70

自引率

4.00%

发文量

367

审稿时长

2 months

期刊介绍： The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.