Exposure to Artificial Light at Night Alters Ultradian Rhythms in Endothelial Function.

IF 2.3 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE
James C Walton, O Hecmarie Meléndez-Fernández, A Courtney DeVries, Paul D Chantler, Randy J Nelson
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引用次数: 0

Abstract

Introduction: Endogenous biological timing mechanisms are fundamental aspects of living cells, tissues, and organisms. Virtually every aspect of physiology and behavior is mediated by self-sustaining circadian clocks, which depend on light to synchronize with the external daily environment. However, exposure to artificial light at night (ALAN) can impair temporal adaptations and affect health and disease.

Methods: During a study of the effects of long-term ALAN exposure on cardiovascular function, we serendipitously detected ultradian rhythms in muscarinic receptor dependent relaxation of isolated aortic tissue.

Results and conclusion: Mice exposed to dark nights displayed an ultradian pattern of maximum endothelial-dependent relaxation that was antiphase between the sexes. Rhythmic patterns of relaxation were abolished by ALAN exposure in both sexes suggesting that ALAN exposure can affect ultradian rhythms in physiology and behavior.

夜间暴露于人造光会改变内皮功能的超昼夜节律。
内源性生物定时机制是活细胞、组织和生物体的基本方面。实际上,生理和行为的每一个方面都是由自我维持的生物钟调节的,它依赖于光与外部日常环境同步。然而,夜间暴露于人造光(ALAN)会损害时间适应性,并影响健康和疾病。在一项长期暴露于ALAN对心血管功能影响的研究中,我们偶然发现了离体主动脉组织中毒碱受体依赖性松弛的超昼夜节律。暴露在黑暗夜晚的小鼠表现出内皮依赖性最大放松的超昼夜模式,这在两性之间是相反的。在两性中,暴露于ALAN会破坏放松的节奏模式,这表明暴露于ALAN会影响生理和行为的超昼夜节律。
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来源期刊
Journal of Vascular Research
Journal of Vascular Research 医学-生理学
CiteScore
3.40
自引率
0.00%
发文量
25
审稿时长
>12 weeks
期刊介绍: The ''Journal of Vascular Research'' publishes original articles and reviews of scientific excellence in vascular and microvascular biology, physiology and pathophysiology. The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation. JVR''s ''Vascular Update'' series regularly presents state-of-the-art reviews on hot topics in vascular biology. Manuscript processing times are, consistent with stringent review, kept as short as possible due to electronic submission. All articles are published online first, ensuring rapid publication. The ''Journal of Vascular Research'' is the official journal of the European Society for Microcirculation. A biennial prize is awarded to the authors of the best paper published in the journal over the previous two years, thus encouraging young scientists working in the exciting field of vascular biology to publish their findings.
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