Overcoming resistance: targeted nanomedicine solutions for cancer therapy.

Abstract

Multidrug resistance (MDR), or tumor drug resistance, is still one of the most serious issues in the treatment of cancer, which directly affects the efficacy of cancer therapies and the survival of patients. This review focuses on describing how nanotechnology in medicine may help to address MDR and presents novel approaches that may revolutionize targeted cancer treatment. In this review, we discuss the potential of different types of nanoparticles, such as liposomes, polymeric nanoparticles and metallic nanoparticles for targeted delivery, and the use of these nanoparticles to kill tumor cells without damaging the normal cells. Further, we discuss emerging approaches, including RNA interference, CRISPR-Cas9 gene editing, and stimuli-responsive nanoparticles, all of which indicate future directions for MDR combat. Based on such developments, nanomedicine turns out to be a crucial handle in oncology, end-user for superior and refine style of managing cancer. This review establishes the imperative practicing of transdisciplinary integration in order to attain the optimum advancement of nanomedicine in combating MDR and enhancing the survival prognosis of different forms of cancer in patients all over the world.