Transplant failure in relation to BK viremia status among kidney transplant recipients in Jordan.

IF 1.7 Q4 MICROBIOLOGY

Iranian Journal of Microbiology Pub Date : 2025-08-01 DOI:10.18502/ijm.v17i4.19256

Rabaa Y Athamneh, Reema Bani Saeed, Omaymah Abulannaz, Rawan Abudalo, Muna Oqal

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Abstract

Background and objectives: BK polyomavirus (BKPyV) poses a significant threat to kidney transplant (KT) recipients due to immunosuppression, leading to BK-associated nephropathy (BKVN) and reduced transplant survival. This study aimed to determine the prevalence of BKPyV among kidney transplant recipients in Jordan and to evaluate the association between BKPyV activity and kidney transplant outcomes.

Materials and methods: A retrospective observational study was conducted at the Jordanian Royal Medical Services Hospital (JRMS) from 2021 to 2024. Blood samples (n=157) from kidney transplant recipients were collected, and quantitative real-time PCR was performed to detect BKPyV DNA.

Results: The prevalence of BKPyV infection among kidney transplant recipients was 40.8% (n=64). Transplant failure occurred in 36% of cases (n=57), with BKPyV-DNA viremia observed in 74% of those with transplant failure (n=42). The prevalence of infection was significantly higher in patients under 18 years of age (81%, p<0.001) and in males (72%, p<0.001). BKPyV infection increased the odds of transplant failure tenfold.

Conclusion: In Jordan, the prevalence of BKPyV among kidney transplant recipients is high, particularly in males and younger patients. BKPyV significantly increases the risk of kidney transplant failure. Other studies are needed to further elucidate the impact of BKPyV on kidney transplant rejection and complications.

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移植失败与约旦肾移植受者BK病毒血症状态的关系

背景和目的：BK多瘤病毒（BKPyV）由于免疫抑制对肾移植（KT）受者构成重大威胁，导致BK相关性肾病（BKVN）和移植存活率降低。本研究旨在确定约旦肾移植受者中BKPyV的患病率，并评估BKPyV活性与肾移植结果之间的关系。材料和方法：从2021年到2024年在约旦皇家医疗服务医院（JRMS）进行了一项回顾性观察研究。收集肾移植受者157例血样，采用实时荧光定量PCR检测BKPyV DNA。结果：肾移植受者BKPyV感染率为40.8% （n=64）。36%的病例（n=57）发生移植失败，74%的移植失败患者（n=42）出现BKPyV-DNA病毒血症。结论：在约旦，肾移植受者中BKPyV的患病率很高，特别是在男性和年轻患者中。BKPyV显著增加肾移植失败的风险。BKPyV对肾移植排斥反应及其并发症的影响尚需进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Microbiology MICROBIOLOGY-

CiteScore

2.40

自引率

7.10%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Journal of Microbiology (IJM) is an international, multi-disciplinary, peer-reviewed journal that provides rapid publication of the most advanced scientific research in the areas of basic and applied research on bacteria and other micro-organisms, including bacteria, viruses, yeasts, fungi, microalgae, and protozoa concerning the development of tools for diagnosis and disease control, epidemiology, antimicrobial agents, clinical microbiology, immunology, Genetics, Genomics and Molecular Biology. Contributions may be in the form of original research papers, review articles, short communications, case reports, technical reports, and letters to the Editor. Research findings must be novel and the original data must be available for review by the Editors, if necessary. Studies that are preliminary, of weak originality or merely descriptive as well as negative results are not appropriate for the journal. Papers considered for publication must be unpublished work (except in an abstract form) that is not under consideration for publication anywhere else, and all co-authors should have agreed to the submission. Manuscripts should be written in English.