{"title":"The prevalence of pediatric nosocomial fungal infections.","authors":"Parisa Badiee, Hadis Jafarian","doi":"10.18502/ijm.v17i4.19258","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objectives: </strong>The aim of this study was to identify the incidence of nosocomial fungal infections in pediatric patients and evaluate the etiological agents, risk factors, and sites of infections.</p><p><strong>Materials and methods: </strong>Clinical samples were cultured to assess fungal colonization. When fungal nosocomial infections were suspected according to the European Organization for Research and Treatment of Cancer criteria, clinical samples were evaluated using direct microscopic, culture, and molecular methods. Susceptibility patterns of the isolates were evaluated according to the Clinical and Laboratory Standard Institute.</p><p><strong>Results: </strong>From the 1450 patients, 190 cases (5.5%) were evaluated for nosocomial fungal infections. <i>Candida</i> colonization was observed in 35 (18.4%) patients. The rate of nosocomial fungal infections in pediatrics was 2.69% (12 cases with proven and 27 cases with probable infections, 39/1450). Bloodstream and lungs were the frequent infected sites of patients' body. <i>Aspergillus</i> species (<i>Aspergillus flavus</i> and <i>Aspergillus fumigatus</i>), <i>Candida</i> species (<i>Candida albicans, Candida parapsilosis, Candida glabrata</i>) and Mucorales were the etiologic agents of infections. Caspofungin and luliconazole were effective antifungal agents for isolated fungi. The rate of mortality in infected patients suffering from proven and probable infections was 15.4% (6/39 cases).</p><p><strong>Conclusion: </strong>Due to the high mortality rates of fungal infections in pediatrics, it is essential to identify modifiable risk factors, and implement control measures along with early detection techniques in pediatric populations.</p>","PeriodicalId":14633,"journal":{"name":"Iranian Journal of Microbiology","volume":"17 4","pages":"644-652"},"PeriodicalIF":1.7000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331464/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/ijm.v17i4.19258","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
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Abstract
Background and objectives: The aim of this study was to identify the incidence of nosocomial fungal infections in pediatric patients and evaluate the etiological agents, risk factors, and sites of infections.
Materials and methods: Clinical samples were cultured to assess fungal colonization. When fungal nosocomial infections were suspected according to the European Organization for Research and Treatment of Cancer criteria, clinical samples were evaluated using direct microscopic, culture, and molecular methods. Susceptibility patterns of the isolates were evaluated according to the Clinical and Laboratory Standard Institute.
Results: From the 1450 patients, 190 cases (5.5%) were evaluated for nosocomial fungal infections. Candida colonization was observed in 35 (18.4%) patients. The rate of nosocomial fungal infections in pediatrics was 2.69% (12 cases with proven and 27 cases with probable infections, 39/1450). Bloodstream and lungs were the frequent infected sites of patients' body. Aspergillus species (Aspergillus flavus and Aspergillus fumigatus), Candida species (Candida albicans, Candida parapsilosis, Candida glabrata) and Mucorales were the etiologic agents of infections. Caspofungin and luliconazole were effective antifungal agents for isolated fungi. The rate of mortality in infected patients suffering from proven and probable infections was 15.4% (6/39 cases).
Conclusion: Due to the high mortality rates of fungal infections in pediatrics, it is essential to identify modifiable risk factors, and implement control measures along with early detection techniques in pediatric populations.
期刊介绍：
The Iranian Journal of Microbiology (IJM) is an international, multi-disciplinary, peer-reviewed journal that provides rapid publication of the most advanced scientific research in the areas of basic and applied research on bacteria and other micro-organisms, including bacteria, viruses, yeasts, fungi, microalgae, and protozoa concerning the development of tools for diagnosis and disease control, epidemiology, antimicrobial agents, clinical microbiology, immunology, Genetics, Genomics and Molecular Biology. Contributions may be in the form of original research papers, review articles, short communications, case reports, technical reports, and letters to the Editor. Research findings must be novel and the original data must be available for review by the Editors, if necessary. Studies that are preliminary, of weak originality or merely descriptive as well as negative results are not appropriate for the journal. Papers considered for publication must be unpublished work (except in an abstract form) that is not under consideration for publication anywhere else, and all co-authors should have agreed to the submission. Manuscripts should be written in English.
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