The Impact of Cholecystectomy on Colorectal Cancer Risk: A Comprehensive Review on Risk Factors and the Association.

Q1 Medicine

Current Gastroenterology Reports Pub Date : 2025-08-11 DOI:10.1007/s11894-025-01008-z

Parsa Lorestani, Ferdos Faghihkhorasani, Homina Saffar, Behnam Darabi, Yasaman Tavakoli, Amir Mohammad Lorestani, Mohammad Ghiasi, Kimia Jazi

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引用次数: 0

Abstract

Purpose of review: This review examines the debated association between cholecystectomy and colorectal cancer risk. The goal is to evaluate biological mechanisms, epidemiological evidence, and related risk factors to better understand this potential association.

Recent findings: Cholecystectomy may increase CRC risk through altered bile acid metabolism and gut microbiota changes, particularly in the right colon. Epidemiological studies, however, yield mixed outcomes: some show a heightened CRC risk following surgery, especially in women and for proximal colon cancers, while others find no notable link or even a lower risk compared to individuals with untreated gallstones. No clear consensus exists on the cholecystectomy-CRC link. Biological evidence hints at a possible connection, yet epidemiological findings are inconsistent, calling for more prospective research to resolve this uncertainty. Until conclusive answers emerge, high-risk patients' post-cholecystectomy may benefit from enhanced CRC screening and lifestyle adjustments, influencing future clinical and research directions.

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胆囊切除术对结直肠癌风险的影响：危险因素及其相关性的综合综述。

综述目的：本综述探讨了胆囊切除术与结直肠癌风险之间存在争议的关系。目的是评估生物学机制、流行病学证据和相关危险因素，以更好地了解这种潜在关联。最近发现：胆囊切除术可能通过改变胆汁酸代谢和肠道菌群改变而增加结直肠癌的风险，特别是在右结肠。然而，流行病学研究得出了不同的结果：一些研究显示手术后结直肠癌的风险增加，特别是在女性和近端结肠癌中，而另一些研究则发现与未经治疗的胆结石患者相比，没有明显的联系，甚至风险更低。关于胆囊切除术与结直肠癌的联系尚无明确的共识。生物学证据暗示了可能的联系，但流行病学研究结果却不一致，需要更多的前瞻性研究来解决这种不确定性。在结论性答案出现之前，高危患者胆囊切除术后可能受益于加强CRC筛查和生活方式调整，影响未来的临床和研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Gastroenterology Reports Medicine-Gastroenterology

CiteScore

7.80

自引率

0.00%

发文量

期刊介绍： As the field of gastroenterology and hepatology rapidly evolves, the wealth of published literature can be overwhelming. The aim of the journal is to help readers stay abreast of such advances by offering authoritative, systematic reviews by leading experts. We accomplish this aim by appointing Section Editors who invite international experts to contribute review articles that highlight recent developments and important papers published in the past year. Major topics in gastroenterology are covered, including pediatric gastroenterology, neuromuscular disorders, infections, nutrition, and inflammatory bowel disease. These reviews provide clear, insightful summaries of expert perspectives relevant to clinical practice. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.