Relationship between eosinopenia and neutrophil-lymphocyte ratio with sepsis-related mortality in the intensive care unit.

IF 1 Q3 MEDICINE, GENERAL & INTERNAL

Caspian Journal of Internal Medicine Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI:10.22088/cjim.16.3.444

Parviz Amri, Armin Nejadnaderi, Hemmat Gholinia, Fatemeh Heidarnia, Masomeh Bayani

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Abstract

Background: Early diagnosis of sepsis can lead to rapid initiation of treatment and reduced mortality. The aim of this study was to investigate the relationship between eosinopenia and neutrophil-lymphocyte ratio (NLR) with sepsis-related mortality in the intensive care unit.

Results: Out of 100 patients studied, 59 patients survived and 41 patients died and the mean age of the patients was 63.27±16.13 years. Out of 40 patients with eosinopenia, 19(46.3%) died and out of 60 patients with normal eosinophil, 22(53.7%) died (P=0.28). The NLR on the first day in died patients was significantly higher than in the surviving patients (P=0.009). The increase in SOFA Score (p<0.001 and OR=1.49) and the increase in NLR (P=0.02 and OR=3.38) has a direct relationship with the mortality rate.

Conclusion: The results of the present study in sepsis patients showed that patients who had a higher neutrophil-to-lymphocyte ratio had higher mortality and there was no relationship between eosinopenia and mortality rate.

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重症监护病房中嗜酸性粒细胞减少和中性粒细胞淋巴细胞比值与败血症相关死亡率的关系。

背景：败血症的早期诊断可以导致快速开始治疗和降低死亡率。本研究的目的是探讨重症监护病房中嗜酸性粒细胞减少和中性粒细胞淋巴细胞比（NLR）与败血症相关死亡率的关系。结果：100例患者中，存活59例，死亡41例，平均年龄63.27±16.13岁。40例嗜酸性粒细胞减少患者中死亡19例（46.3%），60例嗜酸性粒细胞正常患者中死亡22例（53.7%）（P=0.28）。死亡患者第1天NLR显著高于存活患者（P=0.009）。结论：本研究结果显示，脓毒症患者中性粒细胞与淋巴细胞比值较高的患者死亡率较高，嗜酸性粒细胞减少与死亡率无相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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