Impact of HbA1c levels on coronary SYNTAX score in non-diabetic patients with ST-elevation myocardial infarction undergoing primary angioplasty: A cross-sectional study.

IF 1 Q3 MEDICINE, GENERAL & INTERNAL

Caspian Journal of Internal Medicine Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI:10.22088/cjim.16.3.519

Majid Saraei Koushki, Razieh Parizad, Ali Abdollahzadeh, Ahmad Separham

{"title":"Impact of HbA1c levels on coronary SYNTAX score in non-diabetic patients with ST-elevation myocardial infarction undergoing primary angioplasty: A cross-sectional study.","authors":"Majid Saraei Koushki, Razieh Parizad, Ali Abdollahzadeh, Ahmad Separham","doi":"10.22088/cjim.16.3.519","DOIUrl":null,"url":null,"abstract":"Background: Glycated hemoglobin A1c (HbA1c) level is related to increased cardiovascular diseases (CVDs) and death, even in non-diabetic subjects. Although in ST-elevation myocardial infarction (STEMI) cases, the association between HbA1c and coronary artery disease (CAD) remains unclear.Methods: This cross-sectional study was conducted on 167 non-diabetic STEMI patients undergoing primary percutaneous coronary intervention (PCI). The SYNTAX score was utilized to evaluate CAD severity. Cases were categorized into three groups based on the HbA1c levels: <5%, 5.1-5.9%, and 6-6.5%.Results: SYNTAX scores significantly increased in the cases with 6 to 6.5 HbA1c levels compared to the other group (28.9±9.5 vs 21.2±5.2 vs 13.7±4.5, P=0.000). Additionally, death was more elevated in this group (4% vs 0% vs 0%, P=0.006).Conclusion: Higher HbA1c levels are strongly associated with coronary atherosclerosis in non-diabetic patients that present with non-diabetic STEMI. Consequently, in non-diabetic STEMI patients, HbA1c may be able to predict the severity of CAD.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"519-524"},"PeriodicalIF":1.0000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329363/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Caspian Journal of Internal Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22088/cjim.16.3.519","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Glycated hemoglobin A1c (HbA1c) level is related to increased cardiovascular diseases (CVDs) and death, even in non-diabetic subjects. Although in ST-elevation myocardial infarction (STEMI) cases, the association between HbA1c and coronary artery disease (CAD) remains unclear.

Methods: This cross-sectional study was conducted on 167 non-diabetic STEMI patients undergoing primary percutaneous coronary intervention (PCI). The SYNTAX score was utilized to evaluate CAD severity. Cases were categorized into three groups based on the HbA1c levels: <5%, 5.1-5.9%, and 6-6.5%.

Results: SYNTAX scores significantly increased in the cases with 6 to 6.5 HbA1c levels compared to the other group (28.9±9.5 vs 21.2±5.2 vs 13.7±4.5, P=0.000). Additionally, death was more elevated in this group (4% vs 0% vs 0%, P=0.006).

Conclusion: Higher HbA1c levels are strongly associated with coronary atherosclerosis in non-diabetic patients that present with non-diabetic STEMI. Consequently, in non-diabetic STEMI patients, HbA1c may be able to predict the severity of CAD.

查看原文本刊更多论文

非糖尿病st段抬高型心肌梗死患者行原发性血管成形术时HbA1c水平对冠状动脉SYNTAX评分的影响：一项横断面研究

背景：糖化血红蛋白（HbA1c）水平与心血管疾病（cvd）和死亡的增加有关，即使在非糖尿病受试者中也是如此。尽管在st段抬高型心肌梗死（STEMI）病例中，HbA1c与冠状动脉疾病（CAD）之间的关系尚不清楚。方法：本横断面研究对167例非糖尿病STEMI患者进行了经皮冠状动脉介入治疗（PCI）。SYNTAX评分用于评估CAD的严重程度。根据HbA1c水平将病例分为三组：结果：与其他组相比，HbA1c水平为6至6.5的患者SYNTAX评分显著升高（28.9±9.5 vs 21.2±5.2 vs 13.7±4.5，P=0.000）。此外，该组的死亡率更高（4% vs 0% vs 0%， P=0.006）。结论：在非糖尿病STEMI患者中，较高的HbA1c水平与冠状动脉粥样硬化密切相关。因此，在非糖尿病STEMI患者中，HbA1c可能能够预测CAD的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊