Comparing the results of knee osteoarthritis treatment with intra-articular injection of steroid (methylprednisolone) and hyaluronic acid.

IF 1 Q3 MEDICINE, GENERAL & INTERNAL
Caspian Journal of Internal Medicine Pub Date : 2025-06-22 eCollection Date: 2025-01-01 DOI:10.22088/cjim.16.3.437
Seyyed Reza Aghapour, Hamid Mohammadi, Seyyed Poyan Aghapour, Khashayar Farnoud, Yasin Sharifzadeh
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引用次数: 0

Abstract

Background: Treatments for osteoarthritis, including steroids and nonsteroidal anti-inflammatory drugs, are not very satisfactory. Therefore, we decided to compare the therapeutic results of intra-articular injection of hyaluronic acid and methylprednisolone.

Methods: In this single-blind clinical trial, 132 patients with osteoarthritis of the knee were randomly assigned to two treatment groups; hyaluronic acid and methylprednisolone. Treatment results were measured based on the standard McMaster Universities Arthritis Index (WOMAC) questionnaire.

Results: Although the desired level of satisfaction was higher in the short-term in the methylprednisolone group and in the long-term in the hyaluronic acid group, however, these differences were not significant.

Conclusion: The recovery of patients is better with methylprednisolone injection in the short term and hyaluronic acid in the long term. However, since methylprednisolone has complications, it is recommended to consider hyaluronic acid as a suitable drug in the treatment process.

关节内注射类固醇(甲基强的松龙)和透明质酸治疗膝关节骨性关节炎的效果比较。
背景:骨关节炎的治疗,包括类固醇和非类固醇抗炎药,不是很令人满意。因此,我们决定比较关节内注射透明质酸和甲基强的松龙的治疗效果。方法:在单盲临床试验中,132例膝关节骨性关节炎患者随机分为两个治疗组;透明质酸和甲基强的松龙。治疗结果根据麦克马斯特大学关节炎指数(WOMAC)标准问卷进行测量。结果:甲基强的松龙组短期满意度高于透明质酸组长期满意度,但差异不显著。结论:甲强的松龙注射液短期疗效较好,透明质酸注射液长期疗效较好。然而,由于甲基强的松龙有并发症,建议在治疗过程中考虑透明质酸作为合适的药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Caspian Journal of Internal Medicine
Caspian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
1.90
自引率
7.10%
发文量
90
审稿时长
20 weeks
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