Recurrence and metastasis of cutaneous and subcutaneous tumors following excision with advanced surgical margin assessment.

IF 1 4区农林科学 Q3 VETERINARY SCIENCES

Canadian Veterinary Journal-revue Veterinaire Canadienne Pub Date : 2025-08-01

Carley P Johnson, Gabrielle S Fontes, Edward Cheng, Ryan N Jennings, Janis M Lapsley, Hunter J Piegols, Laura E Selmic

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引用次数: 0

Abstract

Background: Surgical margin status can affect the risk for recurrence in dogs with cutaneous and subcutaneous masses. Histopathology is the current gold standard for margin assessment, despite evaluating small amounts of the surgical margin. Optical coherence tomography (OCT) has been described for surgical margin assessment following the excision of canine cutaneous and subcutaneous tumors.

Objective: To assess the rates of recurrence and metastasis following excision with an incomplete margin on OCT and confirmed with histopathology.

Animals and procedure: Seventy-one excised canine cutaneous and subcutaneous tumors underwent OCT imaging and histopathologic assessment.

Results: Of 61 tumors, 51 were malignant, including 21 soft tissue sarcomas and 21 mast cell tumors. Ten dogs experienced local tumor recurrence, with 7/10 and 8/10 having incomplete margins on OCT and histopathology, respectively. Ten dogs experienced distant metastasis, with 6/10 and 8/10 having incomplete margins on OCT and histopathology, respectively.

Conclusion and clinical relevance: Local recurrence occurred in tumors with predominately incomplete margins following advanced surgical margin assessment; however, not all tumors with incomplete margins developed local recurrence. Further prospective research is needed to assess the effect of entire surgical margin imaging on patient outcomes.

本刊更多论文

皮肤及皮下肿瘤切除后的复发及转移及手术边缘评估。

背景：手术切缘状况会影响狗的皮肤和皮下肿块的复发风险。组织病理学是目前评估切缘的金标准，尽管评估少量手术切缘。光学相干断层扫描（OCT）已被描述为手术边缘评估后，切除犬皮肤和皮下肿瘤。目的：探讨经OCT检查并经组织病理学证实的切缘不全切除后的复发和转移率。动物和手术：71例切除的犬皮肤和皮下肿瘤行OCT成像和组织病理学评估。结果：61例肿瘤中，恶性51例，其中软组织肉瘤21例，肥大细胞瘤21例。10只犬出现局部肿瘤复发，其中7/10和8/10分别在OCT和组织病理学上表现为边缘不全。10只狗发生远处转移，其中6/10和8/10分别在OCT和组织病理学上有不完整的边缘。结论及临床意义：晚期手术切缘评估后，以切缘不全为主的肿瘤发生局部复发；然而，并非所有边缘不完整的肿瘤都会发生局部复发。需要进一步的前瞻性研究来评估整个手术缘成像对患者预后的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Canadian Veterinary Journal-revue Veterinaire Canadienne 农林科学-兽医学

CiteScore

1.20

自引率

10.00%

发文量

177

审稿时长

12-24 weeks

期刊介绍： The Canadian Veterinary Journal (CVJ) provides a forum for the discussion of all matters relevant to the veterinary profession. The mission of the Journal is to educate by informing readers of progress in clinical veterinary medicine, clinical veterinary research, and related fields of endeavor. The key objective of The CVJ is to promote the art and science of veterinary medicine and the betterment of animal health. A report suggesting that animals have been unnecessarily subjected to adverse, stressful, or harsh conditions or treatments will not be processed for publication. Experimental studies using animals will only be considered for publication if the studies have been approved by an institutional animal care committee, or equivalent, and the guidelines of the Canadian Council on Animal Care, or equivalent, have been followed by the author(s).