Alessandra Griffa, Francois Rheault, Alessandro Daducci, Andrew Zalesky
{"title":"A thousand ways to tailor your tractography-based connectome.","authors":"Alessandra Griffa, Francois Rheault, Alessandro Daducci, Andrew Zalesky","doi":"10.1007/s00429-025-02998-2","DOIUrl":null,"url":null,"abstract":"<p><p>Did you know that there are thousands of ways to build a connectome from diffusion MRI tractography, and the choice of approach can hugely impact the final connectome and results? To name only a few: Tractography type: deterministic or probabilistic? Parcellation resolution: coarse or fine atlas? Edge weighting: streamline count, length, or microstructural properties? These choices give rise to a daunting garden of forking paths. In this article, we revise fundamental decisions you must make when planning to build a tractography-based connectome and their impact on its network analysis.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 7","pages":"130"},"PeriodicalIF":2.9000,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Structure & Function","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00429-025-02998-2","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ANATOMY & MORPHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Did you know that there are thousands of ways to build a connectome from diffusion MRI tractography, and the choice of approach can hugely impact the final connectome and results? To name only a few: Tractography type: deterministic or probabilistic? Parcellation resolution: coarse or fine atlas? Edge weighting: streamline count, length, or microstructural properties? These choices give rise to a daunting garden of forking paths. In this article, we revise fundamental decisions you must make when planning to build a tractography-based connectome and their impact on its network analysis.
期刊介绍:
Brain Structure & Function publishes research that provides insight into brain structure−function relationships. Studies published here integrate data spanning from molecular, cellular, developmental, and systems architecture to the neuroanatomy of behavior and cognitive functions. Manuscripts with focus on the spinal cord or the peripheral nervous system are not accepted for publication. Manuscripts with focus on diseases, animal models of diseases, or disease-related mechanisms are only considered for publication, if the findings provide novel insight into the organization and mechanisms of normal brain structure and function.