The Role of Lactate in Mitochondrial Metabolism of DOX-Induced Senescent AC16 Cells

IF 2.7 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Function Pub Date : 2025-08-12 DOI:10.1002/cbf.70110

Rosamaria Militello, Simone Luti, Tania Gamberi, Manuela Leri, Alice Santi, Matteo Becatti, Alessio Pellegrino, Pietro Amedeo Modesti, Alessandra Modesti

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引用次数: 0

Abstract

Senescent cells accumulate with age in organ and tissue causing the decline of functionality and various pathological conditions including cardiovascular disease. Regular exercise induces continuous exposure to lactate that contribute to adaptive process through mitochondrial biogenesis and improve of metabolic process. Lactate accumulation during exercise also appears to be associated with exercise-induced mitochondrial adaptation. Improvement of mitochondria function through lactate exposure could be a tool to prevent cardiomyocytes senescence and cardiac aging. The aim of the following article is to investigate the role of lactate in Doxorubicin-induced senescent AC16 human cardiomyocytes cell mitochondrial metabolism. We assessed the metabolic behaviour in senescent cardiomyocytes after chronic lactate exposure and provided a discussion of the effect of this metabolite in regulating mitochondrial physiology during cardiac aging.

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乳酸在dox诱导的衰老AC16细胞线粒体代谢中的作用

随着年龄的增长，衰老细胞在器官和组织中积累，导致功能下降和各种病理状况，包括心血管疾病。有规律的运动诱导持续的乳酸暴露，通过线粒体生物发生促进适应过程，改善代谢过程。运动期间乳酸积累似乎也与运动诱导的线粒体适应有关。通过乳酸暴露改善线粒体功能可能是防止心肌细胞衰老和心脏老化的一种工具。下面这篇文章的目的是研究乳酸在阿霉素诱导的衰老AC16人心肌细胞线粒体代谢中的作用。我们评估了慢性乳酸暴露后衰老心肌细胞的代谢行为，并讨论了这种代谢物在心脏衰老过程中调节线粒体生理的作用。

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来源期刊

Cell Biochemistry and Function 生物-生化与分子生物学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Biochemistry and Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease. The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies of cells in situ are especially encouraged. Observational and pathological studies will be considered providing they include a rational discussion of the possible molecular and biochemical mechanisms behind them and the immediate impact of these observations to our understanding of mammalian biology.