Platelet Membrane Biomimetic Chemiluminescent Nanoparticles for Targeted Therapy of Atherosclerosis

IF 8.2 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2025-08-10 DOI:10.1021/acsami.5c10093

Qianru Zhou, Maoqing Huang, Yujie Wang and Dan Mu*,

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引用次数: 0

Abstract

Photodynamic therapy (PDT) scavenges diseased cells by using photosensitizers, excitation light, and oxygen. Conventional PDT relies on external excitation light. The depth of penetration of the excitation light is limited, and atherosclerotic plaques are located deep in the tissue, which is not conducive to atherosclerosis treatment. In this study, self-luminescent nanoparticles, platelet membrane (PM)-coated PLGA nanoparticles containing the photosensitizer chlorin e6 (Ce6) and bis(2,4,5-trichloro-6-[pentyloxycarbonyl]phenyl)oxalate (BTPO) (PM@CBNP), are designed for atherosclerosis therapy. After PM@CBNP targeted the plaque, BTPO reacts with H₂O₂, exciting Ce6 to generate singlet oxygen (¹O₂) in the atherosclerotic plaque with overexpressed H₂O₂. The targeting ability and chemiluminescence of PM@CBNP are investigated in vitro and in vivo. In atherosclerotic mice, PM@CBNP eliminate inflammatory macrophages, reduce the expression of inflammatory factors, and prevent the progression of atherosclerosis. PM@CBNP provide an idea for the therapy of atherosclerosis.

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血小板膜仿生化学发光纳米颗粒靶向治疗动脉粥样硬化。

光动力疗法（PDT）通过使用光敏剂、激发光和氧气清除病变细胞。传统的PDT依赖于外部激发光。激发光的穿透深度有限，动脉粥样硬化斑块位于组织深处，不利于动脉粥样硬化的治疗。在这项研究中，自发光纳米粒子，血小板膜（PM）包被的PLGA纳米粒子含有光敏剂氯e6 （Ce6）和双（2,4,5-三氯-6-[戊氧羰基]苯基）草酸酯（BTPO）（PM@CBNP），被设计用于动脉粥样硬化治疗。PM@CBNP靶向斑块后，BTPO与H2O2反应，激发Ce6在动脉粥样硬化斑块中产生单线态氧（1O2），过氧化氢表达过高。研究了PM@CBNP在体内和体外的靶向性和化学发光性能。在动脉粥样硬化小鼠中，PM@CBNP消除炎性巨噬细胞，降低炎症因子的表达，阻止动脉粥样硬化的进展。PM@CBNP为动脉粥样硬化的治疗提供了思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.