Effect of switching from intermittently scanned to real-time continuous glucose monitoring on glycaemic outcomes in adults with type 1 diabetes: A real-world, Canadian retrospective study

IF 3.4 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Lisa Chu, Alexander Abitbol
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引用次数: 0

Abstract

Aims

This study investigated the real-world clinical outcomes of switching from intermittently scanned continuous glucose monitoring (isCGM) to real-time CGM (rtCGM) in adults with type 1 diabetes (T1D) from a large Canadian speciality care population.

Methods

This retrospective observational study examined data from January 1, 2018, through July 31, 2023, in the Canadian LMC Diabetes Registry. The analysis measured 6–12-month change in HbA1c in adults with T1D who switched from isCGM to rtCGM and compared changes to a propensity score-matched isCGM cohort. Changes in number of hypoglycaemic events, CGM metrics, body weight, and total daily dose (TDD) of insulin were also evaluated at 6–12-month follow-up.

Results

The full T1D rtCGM switch cohort comprised of 136 adults (mean: age 43 years, diabetes duration 20.9 years, baseline HbA1c 67 mmol/mol [8.2%]). For the full cohort, HbA1c was significantly lower at follow-up compared to baseline (∆-7 mmol/mol [∆-0.6%], p < 0.001). The propensity score-matched subset (n = 84) of these participants had a greater HbA1c reduction compared to the matched isCGM cohort (n = 84; adjusted mean difference, 5 mmol/mol [0.5%]; p = 0.002). The matched rtCGM switch subset had significantly higher time in range 3.9–10.0 mmol/L and lower time above range >10.0 mmol/L, time below range <3.9 mmol/L, and mean glucose compared to the isCGM cohort. There were no significant differences in hypoglycaemic events, body weight, and insulin TDD between the matched cohorts.

Conclusions

This real-world analysis of adults with T1D showed that switching from isCGM to rtCGM use led to significant improvements in HbA1c and CGM metrics.

Abstract Image

从间歇性扫描切换到实时连续血糖监测对成人1型糖尿病患者血糖结局的影响:一项真实世界的加拿大回顾性研究
目的:本研究调查了来自加拿大大型专科护理人群的成人1型糖尿病(T1D)患者从间歇性扫描连续血糖监测(isCGM)切换到实时血糖监测(rtCGM)的真实临床结果。方法:这项回顾性观察性研究检查了加拿大LMC糖尿病登记处2018年1月1日至2023年7月31日的数据。该分析测量了从isCGM转换为rtCGM的成年T1D患者6-12个月的HbA1c变化,并将变化与倾向评分匹配的isCGM队列进行了比较。在6-12个月的随访中,还评估了低血糖事件数量、CGM指标、体重和胰岛素总日剂量(TDD)的变化。结果:全T1D rtCGM转换队列包括136名成年人(平均年龄43岁,糖尿病病程20.9年,基线HbA1c 67 mmol/mol[8.2%])。对于整个队列,随访时HbA1c与基线相比显着降低(∆-7 mmol/mol[∆-0.6%],p 10.0 mmol/L,低于范围)。结论:对成年T1D患者的实际分析表明,从isCGM切换到rtCGM可显著改善HbA1c和CGM指标。
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来源期刊
Diabetic Medicine
Diabetic Medicine 医学-内分泌学与代谢
CiteScore
7.20
自引率
5.70%
发文量
229
审稿时长
3-6 weeks
期刊介绍: Diabetic Medicine, the official journal of Diabetes UK, is published monthly simultaneously, in print and online editions. The journal publishes a range of key information on all clinical aspects of diabetes mellitus, ranging from human genetic studies through clinical physiology and trials to diabetes epidemiology. We do not publish original animal or cell culture studies unless they are part of a study of clinical diabetes involving humans. Categories of publication include research articles, reviews, editorials, commentaries, and correspondence. All material is peer-reviewed. We aim to disseminate knowledge about diabetes research with the goal of improving the management of people with diabetes. The journal therefore seeks to provide a forum for the exchange of ideas between clinicians and researchers worldwide. Topics covered are of importance to all healthcare professionals working with people with diabetes, whether in primary care or specialist services. Surplus generated from the sale of Diabetic Medicine is used by Diabetes UK to know diabetes better and fight diabetes more effectively on behalf of all people affected by and at risk of diabetes as well as their families and carers.”
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