Differences in the thickness of various layers of the macular in patients with and without serum vitamin D deficiency in type 2 diabetes mellitus patients without diabetic retinopathy

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-08-07 DOI:10.1016/j.pdpdt.2025.104757

Xinyan Ma , Hui Yang , Youjin Pan , Suilian Zheng , Haihua Zheng , Zheren Xia

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引用次数: 0

Abstract

Purpose

To investigate the impact of vitamin D deficiency (VDD) on retinal and choroidal thickness (CT) in patients with diabetes mellitus (DM) without diabetic retinopathy (DR) using swept-source optical coherence tomography (SS-OCT).

Methods

Fifty-six eyes from 56 DM-NDR patients were included and divided into two groups based on serum 25(OH)D levels: VDD Group (25(OH)D ≤ 20 ng/mL, n = 27) and non-VDD Group (25(OH)D > 20 ng/mL, n = 29). Macular OCT imaging (6 × 6 mm) was performed and divided into the foveal region (0–1 mm), parafoveal region (1–3 mm), and perifoveal region (3–6 mm). The latter two zones were further subdivided into four quadrants: temporal, superior, nasal, and inferior (T, S, N, I). Retinal layer (RL), retinal nerve fiber layer (RNFL), ganglion cell layer plus inner plexiform layer (GCL-IPL), and CT were measured. Serum vitamin D levels were quantified using electrochemiluminescence immunoassay (ECLIA).

Results

Significant differences in RL and GCL-IPL thicknesses were observed within the foveal region, and in RNFL thickness across all quadrants in the parafoveal region (p < 0.05). RL thickness showed significant differences in the superior and temporal quadrants (p < 0.05). GCL-IPL thickness showed significant differences in all quadrants except the inferior quadrant (p < 0.05).

Conclusion

VDD is associated with reduced RL, RNFL and GCL-IPL thicknesses, particularly in the parafoveal region, indicating that these layers may serve as sensitive biomarkers for VDD-induced neurodegeneration in diabetic patients. Vitamin D deficiency may be a risk factor for the progression of DR.

查看原文本刊更多论文

无糖尿病视网膜病变的2型糖尿病患者血清维生素D缺乏与无血清维生素D缺乏患者黄斑各层厚度的差异

目的：利用扫描源光学相干断层扫描（SS-OCT）研究维生素D缺乏（VDD）对糖尿病（DM）无糖尿病视网膜病变（DR）患者视网膜和脉络膜厚度（CT）的影响。方法：选取56例DM-NDR患者56只眼，根据血清25(OH)D水平分为VDD组（25(OH)D≤20 ng/mL, n=27）和非VDD组（25(OH)D≤20 ng/mL, n=29）。行黄斑OCT成像（6 × 6 mm），分为中央凹区（0-1 mm）、中央凹旁区（1-3 mm）、中央凹周区（3-6 mm）。后两个区域进一步细分为四个象限：颞、上、鼻和下（T、S、N、I）。测量视网膜层（RL）、视网膜神经纤维层（RNFL）、神经节细胞层及内丛状层（GCL-IPL）及CT。采用电化学发光免疫分析法（ECLIA）定量测定血清维生素D水平。结果：在中央凹区观察到RL和GCL-IPL厚度的显著差异，在中央凹旁区域的所有象限中观察到rfl厚度的显著差异(结论：VDD与RL、RNFL和GCL-IPL厚度的减少有关，特别是在中央凹旁区域，表明这些层可能作为VDD诱导的糖尿病患者神经变性的敏感生物标志物。维生素D缺乏可能是DR进展的一个危险因素。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.