{"title":"Impact of age and allergen type on sensitization changes in children with chronic rhinitis.","authors":"Sucheera Nokkaew, Wanlapa Jotikasthira, Potjanee Kiewngam, Adithep Sawatchai, Watcharoot Kanchongkittiphon, Wiparat Manuyakorn","doi":"10.1016/j.ijporl.2025.112508","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Aeroallergen sensitization evaluation aids in diagnosing and managing chronic rhinitis.</p><p><strong>Objective: </strong>To investigate changes in allergen sensitization over time in children with rhinitis.</p><p><strong>Methods: </strong>Children with chronic rhinitis who underwent aeroallergen skin prick tests (SPT) between 2009 and 2019 were re-evaluated with a second SPT between 2022 and 2024. Sensitization changes were assessed by comparing initial and re-evaluation SPT results. A negative converter was defined as a previously positive test that became negative.</p><p><strong>Results: </strong>Among 300 children (mean age 11.5 years), positive SPT rates increased from 71.3 % to 83.7 % (p < 0.001). House dust mites (HDM) were the most common sensitization (77 %), followed by cockroaches (24 %). Sensitization patterns changed in 56.7 % of children. HDM sensitization increased across all age groups, while cat sensitization rose significantly in those initially tested before age 5. Negative conversion rates varied by allergen, highest for Careless Weed (85.7 %) and lowest for HDM (1.52 %). Children who became negative converters for Bermuda grass had smaller initial wheal sizes than those who remained positive (3 mm vs. 5.8 mm, p = 0.003).</p><p><strong>Conclusion: </strong>Allergen sensitization patterns evolve over time, influenced by allergen type and patient age. Repeat testing may be necessary, especially for children with uncontrolled rhinitis.</p>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"196 ","pages":"112508"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of pediatric otorhinolaryngology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ijporl.2025.112508","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/6 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Aeroallergen sensitization evaluation aids in diagnosing and managing chronic rhinitis.
Objective: To investigate changes in allergen sensitization over time in children with rhinitis.
Methods: Children with chronic rhinitis who underwent aeroallergen skin prick tests (SPT) between 2009 and 2019 were re-evaluated with a second SPT between 2022 and 2024. Sensitization changes were assessed by comparing initial and re-evaluation SPT results. A negative converter was defined as a previously positive test that became negative.
Results: Among 300 children (mean age 11.5 years), positive SPT rates increased from 71.3 % to 83.7 % (p < 0.001). House dust mites (HDM) were the most common sensitization (77 %), followed by cockroaches (24 %). Sensitization patterns changed in 56.7 % of children. HDM sensitization increased across all age groups, while cat sensitization rose significantly in those initially tested before age 5. Negative conversion rates varied by allergen, highest for Careless Weed (85.7 %) and lowest for HDM (1.52 %). Children who became negative converters for Bermuda grass had smaller initial wheal sizes than those who remained positive (3 mm vs. 5.8 mm, p = 0.003).
Conclusion: Allergen sensitization patterns evolve over time, influenced by allergen type and patient age. Repeat testing may be necessary, especially for children with uncontrolled rhinitis.
期刊介绍:
The purpose of the International Journal of Pediatric Otorhinolaryngology is to concentrate and disseminate information concerning prevention, cure and care of otorhinolaryngological disorders in infants and children due to developmental, degenerative, infectious, neoplastic, traumatic, social, psychiatric and economic causes. The Journal provides a medium for clinical and basic contributions in all of the areas of pediatric otorhinolaryngology. This includes medical and surgical otology, bronchoesophagology, laryngology, rhinology, diseases of the head and neck, and disorders of communication, including voice, speech and language disorders.