Exosomal non-coding RNA biomarkers in traumatic brain injury.

IF 2.9 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Clinica Chimica Acta Pub Date : 2026-01-01 Epub Date: 2025-08-07 DOI:10.1016/j.cca.2025.120544
Pulatov Sadriddin, Babajanova Umida, Matyakubov Izzat, Urinov Muso, Toxtiyev Jaxongirbek, Akhmedov Shakhboskhan, Narkulova Soxiba, Muradova Emma, Bekchanova Madina, Shodmonov Iskandar, Kasimov Kabil Kasimovich, Matrizayeva Gulnara Djumaniyazovna, Kurbaniyazova Madina Zafajanovna
{"title":"Exosomal non-coding RNA biomarkers in traumatic brain injury.","authors":"Pulatov Sadriddin, Babajanova Umida, Matyakubov Izzat, Urinov Muso, Toxtiyev Jaxongirbek, Akhmedov Shakhboskhan, Narkulova Soxiba, Muradova Emma, Bekchanova Madina, Shodmonov Iskandar, Kasimov Kabil Kasimovich, Matrizayeva Gulnara Djumaniyazovna, Kurbaniyazova Madina Zafajanovna","doi":"10.1016/j.cca.2025.120544","DOIUrl":null,"url":null,"abstract":"<p><p>Traumatic brain injury (TBI) poses a significant global health challenge, leading to high mortality and morbidity rates. Despite extensive research, effective diagnostic and therapeutic strategies remain limited. This review explores the emerging roles of exosomal non-coding RNAs (ncRNAs) as biomarkers and therapeutic agents in TBI. Exosomes, small extracellular vesicles secreted by various cell types, facilitate intercellular communication and carry diverse ncRNAs that modulate gene expression and cellular functions. The pathogenesis of TBI involves complex inflammatory cascades, in which exosomal ncRNAs play pivotal roles in neuroinflammation, neuronal apoptosis, and secondary injury mechanisms. Key ncRNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been identified as potential biomarkers for diagnosing TBI and predicting outcomes. Additionally, exosomal ncRNAs derived from mesenchymal stem cells (MSCs) show promise in promoting neuroprotection and enhancing recovery through various mechanisms. The review highlights the potential of exosomal ncRNAs in addressing critical unmet needs in TBI management, emphasizing their stability, accessibility, and relevance to disease pathophysiology. However, challenges in standardization, validation, and regulatory pathways must be addressed to facilitate their clinical application. This comprehensive examination underscores the transformative potential of exosomal ncRNAs in TBI diagnosis and treatment, paving the way for future research and clinical innovations.</p>","PeriodicalId":10205,"journal":{"name":"Clinica Chimica Acta","volume":" ","pages":"120544"},"PeriodicalIF":2.9000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinica Chimica Acta","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.cca.2025.120544","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/7 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Traumatic brain injury (TBI) poses a significant global health challenge, leading to high mortality and morbidity rates. Despite extensive research, effective diagnostic and therapeutic strategies remain limited. This review explores the emerging roles of exosomal non-coding RNAs (ncRNAs) as biomarkers and therapeutic agents in TBI. Exosomes, small extracellular vesicles secreted by various cell types, facilitate intercellular communication and carry diverse ncRNAs that modulate gene expression and cellular functions. The pathogenesis of TBI involves complex inflammatory cascades, in which exosomal ncRNAs play pivotal roles in neuroinflammation, neuronal apoptosis, and secondary injury mechanisms. Key ncRNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been identified as potential biomarkers for diagnosing TBI and predicting outcomes. Additionally, exosomal ncRNAs derived from mesenchymal stem cells (MSCs) show promise in promoting neuroprotection and enhancing recovery through various mechanisms. The review highlights the potential of exosomal ncRNAs in addressing critical unmet needs in TBI management, emphasizing their stability, accessibility, and relevance to disease pathophysiology. However, challenges in standardization, validation, and regulatory pathways must be addressed to facilitate their clinical application. This comprehensive examination underscores the transformative potential of exosomal ncRNAs in TBI diagnosis and treatment, paving the way for future research and clinical innovations.

外伤性脑损伤的外泌体非编码RNA生物标志物。
外伤性脑损伤(TBI)是一项重大的全球健康挑战,导致高死亡率和发病率。尽管进行了广泛的研究,但有效的诊断和治疗策略仍然有限。本文综述了外泌体非编码rna (ncRNAs)在TBI中作为生物标志物和治疗药物的新作用。外泌体是由各种细胞类型分泌的细胞外小泡,促进细胞间通讯,并携带多种调节基因表达和细胞功能的ncrna。TBI的发病机制涉及复杂的炎症级联反应,其中外泌体ncrna在神经炎症、神经元凋亡和继发性损伤机制中发挥关键作用。关键的ncRNAs,包括长链非编码rna (lncRNAs)和microRNAs (miRNAs),已被确定为诊断TBI和预测预后的潜在生物标志物。此外,来自间充质干细胞(MSCs)的外泌体ncRNAs显示出通过各种机制促进神经保护和增强恢复的希望。该综述强调了外泌体ncrna在解决TBI管理中关键未满足需求方面的潜力,强调了它们的稳定性、可及性和与疾病病理生理学的相关性。然而,必须解决标准化、验证和监管途径方面的挑战,以促进其临床应用。这项全面的研究强调了外泌体ncrna在TBI诊断和治疗中的转化潜力,为未来的研究和临床创新铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Clinica Chimica Acta
Clinica Chimica Acta 医学-医学实验技术
CiteScore
10.10
自引率
2.00%
发文量
1268
审稿时长
23 days
期刊介绍: The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信