Advanced screen-printed electrode functionalized ZnO/CNTs for the electrochemical analysis of opioid drug pethidine co administered with paracetamol: application in dosage form and human plasma sample

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

BMC Chemistry Pub Date : 2025-08-09 DOI:10.1186/s13065-025-01599-8

Shimaa A. Atty, Ahmed M. Abdelzaher, Sona Barghash, Mona A. Abdel Rahman

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引用次数: 0

Abstract

Synthetic opioids such as pethidine (PTD) have a high potential for addiction but are widely used in clinical settings to manage pain before and after surgical procedures. Combinations of pethidine (PTD) with paracetamol (PCM) are frequently prescribed for the treatment of severe and chronic pain. In this study, an eco-friendly voltammetric sensor based on a screen-printed electrode (SPE) modified with zinc oxide nanoparticles functionalized with carbon nanotubes (ZnO/CNTs) was developed and employed. For the first time, the proposed sensor was successfully applied for the determination of pethidine in pharmaceutical formulations, demonstrating excellent recovery. Furthermore, it enabled the simultaneous detection of pethidine and paracetamol in biological samples, with low detection limits of 980 pmol L⁻¹ and 977 pmol L⁻¹ for PTD and PCM, respectively. The sensor offers a promising tool for point of care diagnostics and routine analysis due to its sensitivity, simplicity, and cost-effectiveness.

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先进的丝网印刷电极功能化ZnO/CNTs用于阿片类药物哌替啶与扑热息痛共给药的电化学分析：剂型和人血浆样品的应用。

合成阿片类药物如哌替啶（PTD）具有很高的成瘾可能性，但在临床环境中被广泛用于外科手术前后的疼痛管理。哌替啶（PTD）与扑热息痛（PCM）的组合经常用于治疗严重和慢性疼痛。在本研究中，开发并应用了一种基于碳纳米管功能化氧化锌纳米颗粒修饰的丝网印刷电极（SPE）的环保型伏安传感器。该传感器首次成功应用于药物制剂中哌啶的测定，具有良好的回收率。此外，它还可以同时检测生物样品中的哌啶和对乙酰氨基酚，PTD和PCM的低检出限分别为980 pmol L - 1和977 pmol L - 1。由于其灵敏度、简单性和成本效益，该传感器为点护理诊断和常规分析提供了一个有前途的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Chemistry Chemistry-General Chemistry

CiteScore

5.30

自引率

2.20%

发文量

审稿时长

27 weeks

期刊介绍： BMC Chemistry, formerly known as Chemistry Central Journal, is now part of the BMC series journals family. Chemistry Central Journal has served the chemistry community as a trusted open access resource for more than 10 years – and we are delighted to announce the next step on its journey. In January 2019 the journal has been renamed BMC Chemistry and now strengthens the BMC series footprint in the physical sciences by publishing quality articles and by pushing the boundaries of open chemistry.