Mortality Trends Associated With Acute Myocardial Infarction and Psychoactive Substance Use in Older Adults: A US Nationwide Analysis (1999–2020)

IF 2.3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Muhammad Hamza Shuja, Ramish Hannat, Ahmad Shahid, Komail Khalid Meer, Ayesha Mubbashir, Maliha Edhi, Irfan Ullah, Ahmad Alareed, Nitish Behary Paray, Raheel Ahmed, Bernardo Cortese, Michael E. Hall
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引用次数: 0

Abstract

Background

Acute myocardial infarction (AMI) remains a leading cause of mortality in the USA, particularly among individuals aged 65 and older. There is limited research about the association between psychoactive substance use and cardiovascular death due to AMI. This study aims to analyze trends in AMI-related mortality among older adults (aged ≥ 65) associated with psychoactive substance use in the USA from 1999 to 2020, with a focus on demographic and geographic variations.

Methods

We conducted a descriptive analysis using death certificates from the CDC's WONDER database. Data were extracted for age, sex, race/ethnicity, urban–rural status, and geographic region. Crude mortality rates and AAMR were calculated, and temporal trends were assessed using Joinpoint regression.

Results

Between 1999 and 2020, there were 231 359 AMI-related deaths among older adults with substance use disorders. Men (39.2) had a markedly higher mortality rate than women (15.0). Mortality rates increased across all age groups, with the most pronounced rise in those aged 85 and older (33.9). Metropolitan areas (22.3) experienced lower mortality rates than nonmetropolitan areas (37.9). The Midwest (32.3) consistently recorded the highest mortality rates, followed by the Northeast (25.0), South (24.5), and West (18.7).

Conclusion

The study reveals notable temporal trends in AMI mortality among older adults with psychoactive substance use, highlighting significant demographic and regional disparities. These findings underscore the need for targeted interventions to address this growing public health issue.

Abstract Image

老年人急性心肌梗死和精神活性物质使用相关的死亡率趋势:美国全国范围的分析(1999-2020)
在美国,急性心肌梗死(AMI)仍然是导致死亡的主要原因,尤其是在65岁及以上的人群中。关于精神活性物质使用与AMI所致心血管死亡之间关系的研究有限。本研究旨在分析1999年至2020年美国老年人(≥65岁)与精神活性物质使用相关的ami相关死亡率趋势,重点关注人口统计学和地理差异。方法采用CDC WONDER数据库中的死亡证明进行描述性分析。提取年龄、性别、种族/民族、城乡状况和地理区域的数据。计算粗死亡率和AAMR,并使用连接点回归评估时间趋势。结果1999年至2020年期间,老年物质使用障碍患者中有231 359例ami相关死亡。男性(39.2)的死亡率明显高于女性(15.0)。所有年龄组的死亡率都有所上升,其中85岁及以上年龄组的死亡率上升最为明显(33.9%)。大都市地区(22.3)的死亡率低于非大都市地区(37.9)。死亡率最高的地区依次是中西部(32.3人)、东北部(25.0人)、南部(24.5人)、西部(18.7人)。结论该研究揭示了使用精神活性物质的老年人AMI死亡率的显著时间趋势,突出了显著的人口和地区差异。这些发现强调需要有针对性的干预措施来解决这一日益严重的公共卫生问题。
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来源期刊
Clinical Cardiology
Clinical Cardiology 医学-心血管系统
CiteScore
5.10
自引率
3.70%
发文量
189
审稿时长
4-8 weeks
期刊介绍: Clinical Cardiology provides a fully Gold Open Access forum for the publication of original clinical research, as well as brief reviews of diagnostic and therapeutic issues in cardiovascular medicine and cardiovascular surgery. The journal includes Clinical Investigations, Reviews, free standing editorials and commentaries, and bonus online-only content. The journal also publishes supplements, Expert Panel Discussions, sponsored clinical Reviews, Trial Designs, and Quality and Outcomes.
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