Bactericidal activity of gallic acid against multidrug-resistant Mycobacterium tuberculosis

IF 2.6 3区生物学 Q3 MICROBIOLOGY

Archives of Microbiology Pub Date : 2025-08-11 DOI:10.1007/s00203-025-04422-z

Min Wei, Amirabas Bostani, Nadi Jamalsi, Hasan Baqin, Peng Wen

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引用次数: 0

Abstract

The persistent rise of multidrug-resistant (MDR) bacteria represents a significant public health challenge, necessitating the exploration of alternative therapeutic options. The slow pace of approval for new anti-tuberculosis (TB) medications underscores the urgent need to identify potential alternative agents. Gallic acid (GA) possesses numerous biological properties, including antibacterial and antiseptic effects. In this study, both standard and MDR strains of M. tuberculosis were utilized to assess the antibacterial efficacy of GA and related mechanisms. GA achieved minimum inhibitory and minimum bactericidal concentrations comparable to those of the examined antibiotics with significantly lower cytotoxicity in the THLE-3 cell line (p-value < 0.05). Furthermore, GA displayed bactericidal properties, enhanced the effectiveness of moxifloxacin and levofloxacin against MDR M. tuberculosis, and modulated the expression of efflux pump genes, specifically Rv1410c and Rv1258c (p-value < 0.001). These results contribute to a deeper understanding of GA’s antibacterial potential and suggest a novel alternative approach for managing MDR bacterial infections.

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没食子酸对耐多药结核分枝杆菌的杀菌活性研究

耐多药（MDR）细菌的持续增加是一项重大的公共卫生挑战，有必要探索替代治疗方案。新的抗结核药物批准的缓慢步伐强调了迫切需要确定潜在的替代药物。没食子酸（GA）具有许多生物学特性，包括抗菌和防腐作用。本研究采用标准菌株和耐多药菌株对GA的抑菌效果及其作用机制进行了评价。GA在THLE-3细胞系中的最低抑菌浓度和最低杀菌浓度与所检测的抗生素相当，且细胞毒性显著降低（p值<； 0.05）。此外，GA显示出杀菌特性，增强莫西沙星和左氧氟沙星对耐多药结核分枝杆菌的有效性，并调节外排泵基因的表达，特别是Rv1410c和Rv1258c （p值<； 0.001）。这些结果有助于更深入地了解GA的抗菌潜力，并为管理耐多药细菌感染提供了一种新的替代方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Microbiology 生物-微生物学

CiteScore

4.90

自引率

3.60%

发文量

601

审稿时长

3 months

期刊介绍： Research papers must make a significant and original contribution to microbiology and be of interest to a broad readership. The results of any experimental approach that meets these objectives are welcome, particularly biochemical, molecular genetic, physiological, and/or physical investigations into microbial cells and their interactions with their environments, including their eukaryotic hosts. Mini-reviews in areas of special topical interest and papers on medical microbiology, ecology and systematics, including description of novel taxa, are also published. Theoretical papers and those that report on the analysis or ''mining'' of data are acceptable in principle if new information, interpretations, or hypotheses emerge.