Dual-ligand strategy boosted electrochemiluminescence sensing based on Tb-MOF/Ag3PO4@TCPP

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2025-08-11 DOI:10.1007/s00604-025-07446-w

Yuqi Wu, Xueling Shan, Ziyu Zhao, Ding Jiang, Guoping Yan, Wenchang Wang, Hiroshi Shiigi, Zhibang Hu, Zhidong Chen

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引用次数: 0

Abstract

A dual-ligand strategy was employed to construct an electrochemiluminescence (ECL) sensing platform based on dual-ligand Tb-MOF and Ag₃PO₄@TCPP for sensitive detection of chloramphenicol (CAP), demonstrating its potential applications in environmental monitoring and food safety. The dual-ligand Tb-MOF can be used as a co-reactant promoter, facilitating the rapid electroreduction of S₂O₈²⁻ to generate more oxidative mediator SO₄^•−, thereby enhancing the luminescence efficiency of the luminescent material Ag₃PO₄@TCPP. Furthermore, the integration of Ag₃PO₄@TCPP emitter could effectively overcome the aggregation-caused quenching (ACQ) effect of TCPP and then increase the luminescence intensity by seven-fold, which was attributed to the efficient electron transfer and energy transfer between Ag₃PO₄ and TCPP. Additionally, ECL spectra and electron spin resonance (ESR) spectra were utilized to investigate the possible ECL mechanism of the dual-ligand Tb-MOF/Ag₃PO₄@TCPP system. As a proof of concept, we successfully established an ECL biosensor for detecting CAP, which displayed a wide linear range (10⁻⁶ ~ 10⁻¹⁵ M) and low detection limit (8.29 × 10⁻¹⁶ M), demonstrating practical feasibility. This study introduces a dual-ligand strategy to enhance ECL signals, expands the application scope of dual-ligand lanthanide MOFs, and provides new insights into designing high-performance sensing platforms.

Graphical Abstract

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双配体策略促进了基于Tb-MOF/Ag3PO4@TCPP的电化学发光传感

采用双配体策略构建了基于Tb-MOF和Ag3PO4@TCPP双配体的电化学发光（ECL）传感平台，用于氯霉素（CAP）的灵敏检测，展示了其在环境监测和食品安全领域的潜在应用前景。双配体Tb-MOF可以作为助反应物的促进剂，促进S2O82−的快速电还原生成更多的氧化介质SO4•−，从而提高发光材料的发光效率Ag3PO4@TCPP。此外，Ag3PO4@TCPP发射体的集成可以有效地克服TCPP的聚集猝灭（ACQ）效应，从而使发光强度提高7倍，这是由于Ag3PO4与TCPP之间有效的电子转移和能量转移。此外，利用ECL谱和电子自旋共振（ESR）谱研究了双配体Tb-MOF/Ag3PO4@TCPP体系可能的ECL机制。作为概念验证，我们成功建立了用于CAP检测的ECL生物传感器，该传感器具有宽线性范围（10−6 ~ 10−15 M）和低检测限（8.29 × 10−16 M），证明了实际可行性。本研究引入双配体策略增强ECL信号，拓展了双配体镧系mof的应用范围，为设计高性能传感平台提供了新的见解。图形抽象

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.