Native Australian plants to combat oral health-related pathogens

IF 6.9 1区生物学 Q1 MICROBIOLOGY

Microbiological research Pub Date : 2025-08-06 DOI:10.1016/j.micres.2025.128307

Ratih Pusporini , Maral Seididamyeh , Anh Dao Thi Phan , Run Zhang , Chun Xu , Yasmina Sultanbawa

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引用次数: 0

Abstract

Dental caries remains one of the most prevalent chronic diseases worldwide, impacting health, quality of life, and child development, while posing a substantial economic burden. The rise of antimicrobial resistance has intensified the search for alternative preventive strategies, particularly those derived from natural products. Recent studies highlight that Australian native plants possess significant antimicrobial, antioxidant, and phytochemical properties, suggesting their potential as natural alternatives to synthetic agents.

This review evaluates the therapeutic potential of Australian native plants in preventing dental caries. It examines their bioactive compounds, mechanisms of antimicrobial action, and their application in oral health and dentistry. The review also discusses the traditional and commercial uses of these plants and outlines future research directions.

Findings

reveal that their bioactivity is primarily attributed to phytochemical compounds, which exert antimicrobial, anti-inflammatory, and antioxidant effects—key mechanisms in caries prevention.

Australian native plants demonstrate promising potential as natural therapeutic agents for dental caries prevention. Their incorporation into oral health strategies may contribute to innovative, sustainable solutions in natural product-based drug discovery.

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澳大利亚本土植物对抗口腔健康相关病原体

龋齿仍然是世界上最普遍的慢性疾病之一，影响健康、生活质量和儿童发育，同时造成巨大的经济负担。抗菌素耐药性的上升加强了对替代预防战略的探索，特别是来自天然产品的替代预防战略。最近的研究强调，澳大利亚本土植物具有显著的抗微生物、抗氧化和植物化学特性，表明它们有潜力作为合成药物的天然替代品。本文综述了澳大利亚本土植物在预防龋齿方面的治疗潜力。它检查了它们的生物活性化合物，抗菌作用的机制，以及它们在口腔健康和牙科中的应用。本文还讨论了这些植物的传统用途和商业用途，并概述了未来的研究方向。研究结果表明，它们的生物活性主要归因于具有抗菌、抗炎和抗氧化作用的植物化合物，这是预防龋齿的关键机制。澳大利亚本土植物作为预防龋齿的天然治疗剂显示出巨大的潜力。将它们纳入口腔健康战略可能有助于在基于天然产品的药物发现方面提供创新、可持续的解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiological research 生物-微生物学

CiteScore

10.90

自引率

6.00%

发文量

249

审稿时长

29 days

期刊介绍： Microbiological Research is devoted to publishing reports on prokaryotic and eukaryotic microorganisms such as yeasts, fungi, bacteria, archaea, and protozoa. Research on interactions between pathogenic microorganisms and their environment or hosts are also covered.