Yu Qi, Cheng-Cheng Gu, Hao-Xing Xu, Yu-Hong Tao and Xiao Wang*,
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引用次数: 0
Abstract
At present, imidazoles are predominantly synthesized by the Debus–Radziszewski reaction in batch, a conventional method plagued by issues such as poor selectivity, harsh reaction conditions, and low yield. In this work, a novel continuous-flow process for manufacturing imidazoles has been developed using a specially designed 3D-printed microreactor. This approach offers substantial advantages over the traditional batch synthesis and the existing continuous processes, including higher yields, shorter reaction times, milder conditions, and enhanced scalability. These attributes highlight a potential for industrial-scale production of imidazole and its derivatives, aligning with principles of green chemistry.
期刊介绍：
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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