{"title":"Prognostic and diagnostic value of systemic inflammatory blood markers (NLR, MLR, PLR, AISI, SIRI, and SII) in feline arterial thromboembolism.","authors":"Cagatay Esin, Busra Uzun","doi":"10.1016/j.vetimm.2025.110980","DOIUrl":null,"url":null,"abstract":"<p><p>Feline Arterial Thromboembolism (FATE) is a challenging problem that requires urgent intervention. This study evaluated inflammatory markers' prognostic value in feline arterial thromboembolism (FATE), a devastating cardiac complication often necessitating euthanasia. We analysed inflammatory ratios (NLR, MLR, PLR, AISI, SIRI, SII) and echocardiographic measurements in FATE cats (n = 25) versus controls (n = 10). FATE patients demonstrated significantly elevated inflammatory markers and cardiac measurements. NLR showed strong correlation with cardiac parameters including LA<sub>MAX</sub> (r = 0.629), LA:Ao ratio (r = 0.489), IVSD (r = 0.422), and LVPWD (r = 0.607). Other inflammatory ratios similarly correlated with cardiac measurements. NLR emerged as the most accurate diagnostic biomarker (AUC = 1.000). Median survival time was 334 days overall. Cats with LA<sub>MAX</sub> >18 mm showed reduced survival (213 vs. 333 days). High NLR (>8) was associated with dramatically shortened survival (51 days) compared to moderate (5-8; 174 days) and low NLR (<5; 457 days). Elevated inflammatory markers (NLR >2, MLR >0.15, PLR >80, AISI >276, SIRI >1.08, SII >441) indicate poor prognosis. These accessible biomarkers may assist clinicians in emergency diagnosis confirmation and prognostication of FATE patients.</p>","PeriodicalId":23511,"journal":{"name":"Veterinary immunology and immunopathology","volume":"287 ","pages":"110980"},"PeriodicalIF":1.4000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary immunology and immunopathology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1016/j.vetimm.2025.110980","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/5 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Feline Arterial Thromboembolism (FATE) is a challenging problem that requires urgent intervention. This study evaluated inflammatory markers' prognostic value in feline arterial thromboembolism (FATE), a devastating cardiac complication often necessitating euthanasia. We analysed inflammatory ratios (NLR, MLR, PLR, AISI, SIRI, SII) and echocardiographic measurements in FATE cats (n = 25) versus controls (n = 10). FATE patients demonstrated significantly elevated inflammatory markers and cardiac measurements. NLR showed strong correlation with cardiac parameters including LAMAX (r = 0.629), LA:Ao ratio (r = 0.489), IVSD (r = 0.422), and LVPWD (r = 0.607). Other inflammatory ratios similarly correlated with cardiac measurements. NLR emerged as the most accurate diagnostic biomarker (AUC = 1.000). Median survival time was 334 days overall. Cats with LAMAX >18 mm showed reduced survival (213 vs. 333 days). High NLR (>8) was associated with dramatically shortened survival (51 days) compared to moderate (5-8; 174 days) and low NLR (<5; 457 days). Elevated inflammatory markers (NLR >2, MLR >0.15, PLR >80, AISI >276, SIRI >1.08, SII >441) indicate poor prognosis. These accessible biomarkers may assist clinicians in emergency diagnosis confirmation and prognostication of FATE patients.
期刊介绍：
The journal reports basic, comparative and clinical immunology as they pertain to the animal species designated here: livestock, poultry, and fish species that are major food animals and companion animals such as cats, dogs, horses and camels, and wildlife species that act as reservoirs for food, companion or human infectious diseases, or as models for human disease.
Rodent models of infectious diseases that are of importance in the animal species indicated above,when the disease requires a level of containment that is not readily available for larger animal experimentation (ABSL3), will be considered. Papers on rabbits, lizards, guinea pigs, badgers, armadillos, elephants, antelope, and buffalo will be reviewed if the research advances our fundamental understanding of immunology, or if they act as a reservoir of infectious disease for the primary animal species designated above, or for humans. Manuscripts employing other species will be reviewed if justified as fitting into the categories above.
The following topics are appropriate: biology of cells and mechanisms of the immune system, immunochemistry, immunodeficiencies, immunodiagnosis, immunogenetics, immunopathology, immunology of infectious disease and tumors, immunoprophylaxis including vaccine development and delivery, immunological aspects of pregnancy including passive immunity, autoimmuity, neuroimmunology, and transplanatation immunology. Manuscripts that describe new genes and development of tools such as monoclonal antibodies are also of interest when part of a larger biological study. Studies employing extracts or constituents (plant extracts, feed additives or microbiome) must be sufficiently defined to be reproduced in other laboratories and also provide evidence for possible mechanisms and not simply show an effect on the immune system.
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