Epithelioid sarcoma originating in the chest wall: A case report.

IF 1.1 4区医学 Q3 PATHOLOGY

Medical Molecular Morphology Pub Date : 2025-08-09 DOI:10.1007/s00795-025-00445-z

Yuzo Oyama, Riko Furukawa-Kubota, Hiroko Kadowaki, Junnpei Wada, Kazuhiro Kawamura, Takashi Miura, Tsutomu Daa

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引用次数: 0

Abstract

This report presents the sixth case of chest wall epithelioid sarcoma (ES) in a 71-year-old Japanese man. The patient was incidentally diagnosed with a soft tissue tumor between the eighth and ninth ribs, presenting with an associated bone fracture and osteolytic change. Marginal resection followed by chest wall reconstruction was performed for a definitive diagnosis. Histopathological examination revealed multinodular growth associated with collagenous stroma, mimicking a necrotizing granulomatous process. Various tumor cells were observed, including epithelioid, spindle-shaped, and rhabdoid cells. Immunohistochemical analysis, conducted on trimmed tumor samples without decalcification, revealed positivity for cytokeratin AE1/AE3, vimentin, and CD34, as well as negativity for CK7, CK20, CD31, calretinin, and D2-40. INI expression was completely absent in tumor cells. The patient was diagnosed with ES. The chest wall is an unusual location for ES, and its diagnosis requires differentiation from other epithelioid neoplasms. This case highlights the importance of trimming tumor samples before decalcification to preserve antigenicity and ensure accurate immunohistochemistry analysis.

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起源于胸壁的上皮样肉瘤1例。

本文报告第6例71岁日本男性胸壁上皮样肉瘤（ES）。患者偶然被诊断为第八和第九肋骨之间的软组织肿瘤，并伴有骨折和溶骨改变。边缘切除后胸壁重建进行了明确的诊断。组织病理学检查显示与胶原基质相关的多结节生长，模拟坏死性肉芽肿过程。观察到各种肿瘤细胞，包括上皮样细胞、梭形细胞和横纹肌样细胞。对未脱钙的切除肿瘤样本进行免疫组化分析，发现细胞角蛋白AE1/AE3、vimentin和CD34呈阳性，而CK7、CK20、CD31、calretinin和D2-40呈阴性。肿瘤细胞中完全不表达INI。患者被诊断为ES。胸壁是ES的罕见部位，其诊断需要与其他上皮样肿瘤鉴别。该病例强调了在脱钙前修剪肿瘤样本以保持抗原性和确保准确的免疫组织化学分析的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Molecular Morphology 医学-病理学

CiteScore

2.90

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.