{"title":"Giant Mitotically Active Cellular Fibroma of the Ovary in an a Adolescent.","authors":"Bade Toker Kurtmen, Dilnur Sevinc, Gürdeniz Serin, Emine Burcu Cigsar Kuzu","doi":"10.1016/j.jpag.2025.07.009","DOIUrl":null,"url":null,"abstract":"<p><p>This case report describes a 15-year-old adolescent diagnosed with mitotically active cellular fibroma (MACF) of the ovary. Cellular fibromas account for approximately 10% of all ovarian fibromas. While malignant fibrosarcomas are characterized by aggressive behavior, high mitotic activity, and nuclear atypia, MACFs are considered intermediate tumors, lying between cellular fibromas and fibrosarcomas in terms of mitotic activity and malignant potential. Herein, we present the case of the largest and heaviest MACF mass reported in a pediatric patient in the literature.</p>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pediatric and adolescent gynecology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jpag.2025.07.009","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This case report describes a 15-year-old adolescent diagnosed with mitotically active cellular fibroma (MACF) of the ovary. Cellular fibromas account for approximately 10% of all ovarian fibromas. While malignant fibrosarcomas are characterized by aggressive behavior, high mitotic activity, and nuclear atypia, MACFs are considered intermediate tumors, lying between cellular fibromas and fibrosarcomas in terms of mitotic activity and malignant potential. Herein, we present the case of the largest and heaviest MACF mass reported in a pediatric patient in the literature.
期刊介绍:
Journal of Pediatric and Adolescent Gynecology includes all aspects of clinical and basic science research in pediatric and adolescent gynecology. The Journal draws on expertise from a variety of disciplines including pediatrics, obstetrics and gynecology, reproduction and gynecology, reproductive and pediatric endocrinology, genetics, and molecular biology.
The Journal of Pediatric and Adolescent Gynecology features original studies, review articles, book and literature reviews, letters to the editor, and communications in brief. It is an essential resource for the libraries of OB/GYN specialists, as well as pediatricians and primary care physicians.