Association of HPT axis hormones with metabolic comorbidities among individuals with and without anxiety: A population-based study.

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-12-15 Epub Date: 2025-08-06 DOI:10.1016/j.jad.2025.120006

Rumeng Chen, Zhiwei Zheng, Menghua Liu, Yining Ding, Shuling Xu, Chunyan Hou, Meihua Bao, Binsheng He, Jia Liu, Sen Li

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引用次数: 0

Abstract

Objective: To investigate whether anxiety modifies the association between hypothalamic-pituitary-thyroid (HPT) axis hormone levels and comorbid metabolic disorders (CMDs).

Methods: Data from 7298 NHANES (2007-2012) participants were used to examine associations between HPT axis hormones and CMDs. Weighted logistic and robust Poisson regressions estimated associations; restricted cubic splines (RCS) assessed nonlinear trends; weighted quantile sum (WQS) regression evaluated combined hormone effects. Interaction and stratified analyses were conducted to assess modification by anxiety.

Results: HPT axis hormones showed significant associations with CMDs. Higher FT3 was inversely associated with congestive heart failure (CHF), coronary heart disease (CHD), and diabetes, but positively linked to CMD conditions, hypertension, obesity, dyslipidemia, and Metabolic syndrome (MetS). FT4 was negatively associated with obesity and dyslipidemia, yet positively with CHF, stroke and diabetes. Anxiety significantly modified these associations, notably FT3 with MetS (P_interaction = 0.035) and TT3 with diabetes (P_interaction = 0.001).

Conclusion: HPT axis hormones show significant associations with CMDs, with differing patterns observed across groups. Therefore, it is of clinical significance to pay attention to HPT function in the anxious population.

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HPT轴激素与代谢合并症在有焦虑症和无焦虑症人群中的关联：一项基于人群的研究

目的：探讨焦虑是否改变下丘脑-垂体-甲状腺（HPT）轴激素水平与共病代谢障碍（CMDs）之间的关系。方法：来自7298名NHANES（2007-2012）参与者的数据用于检查HPT轴激素与cmd之间的关系。加权逻辑回归和稳健泊松回归估计关联；限制三次样条（RCS）评估非线性趋势；加权分位数和（WQS）回归评价激素联合作用。通过相互作用和分层分析来评估焦虑的改变。结果：HPT轴激素与CMDs有显著相关性。较高的FT3与充血性心力衰竭（CHF）、冠心病（CHD）和糖尿病呈负相关，但与CMD、高血压、肥胖、血脂异常和代谢综合征（MetS）呈正相关。FT4与肥胖和血脂异常呈负相关，但与心力衰竭、中风和糖尿病呈正相关。焦虑显著地改变了这些关联，特别是FT3与MetS （p - interaction = 0.035）和TT3与糖尿病（p - interaction = 0.001）。结论：HPT轴激素与CMDs有显著的相关性，在不同组中观察到不同的模式。因此，关注焦虑人群的HPT功能具有重要的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.