Association Between Chinese Visceral Adiposity Index and Risk of Incident Hypertension Among Older Adults: A Prospective Cohort Study.

IF 2.9 Q2 PERIPHERAL VASCULAR DISEASE

High Blood Pressure & Cardiovascular Prevention Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI:10.1007/s40292-025-00734-9

Datian Gao, Xuejiao Chen, Dechen Liu, Donghai Su, Yulin Cheng, Yufang Cui, Wanli Hu, Zihao Li, Gefei Li, Xiaoke Zhang, Haiyun Gao, Songhe Shi

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引用次数: 0

Abstract

Introduction: The Chinese visceral adiposity index (CVAI), a favorable surrogate index for assessing visceral fat distribution and function, has been proven to be associated with various conditions, including diabetes mellitus, cardiovascular diseases, and strokes. Nevertheless, evidence on the association of CVAI with the risk of incident hypertension among older adults is limited.

Aim: This study aimed to explore the association between CVAI and the risk of incident hypertension among older adults.

Methods: Data were collected from the annual health examination dataset in Xinzheng, Henan Province from 2018 to 2023. A total of 10,353 participants aged ≥ 60 years were included. Cox proportional hazard models were used to examine the association between CVAI and the risk of incident hypertension by using hazard ratios (HRs) and 95% confidence intervals (CIs). Subgroup and sensitivity analyses were performed to confirm the association's robustness. Additionally, the restricted cubic spline (RCS) was used to fit the dose-response association between CVAI and the risk of incident hypertension.

Results: During a median of 2.72 years of follow-up, hypertension developed in 6990 participants. In the fully-adjusted model, compared with participants in the tertile 1 of CVAI, the tertile 3 (HR = 1.26, 95% CI: 1.19-1.34) of CVAI was associated with an increased risk of incident hypertension and per standard deviation (SD) increase was associated with a 12% (HR = 1.12, 95% CI: 1.09-1.15) increased risk of incident hypertension. Similar significant associations were observed in subgroup and sensitivity analyses. Additionally, the RCS analysis showed a significant dose-response association of CVAI with the risk of incident hypertension (P overall < 0.001 and P nonlinear = 0.238).

Conclusions: These results suggested a positive association between CVAI and the risk of incident hypertension among older adults.

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中国老年人内脏脂肪指数与高血压发生风险的关系：一项前瞻性队列研究。

中国内脏脂肪指数（CVAI）是评估内脏脂肪分布和功能的良好替代指标，已被证明与多种疾病有关，包括糖尿病、心血管疾病和中风。然而，CVAI与老年人高血压发病风险的关联证据有限。目的：本研究旨在探讨CVAI与老年人高血压发病风险之间的关系。方法：收集2018 - 2023年河南省新郑市年度健康体检数据集。共纳入10353名年龄≥60岁的参与者。采用Cox比例风险模型，通过风险比（hr）和95%置信区间（ci）检验CVAI与高血压发病风险之间的关系。进行亚组分析和敏感性分析以证实相关性的稳健性。此外，限制三次样条（RCS）用于拟合CVAI与高血压事件风险之间的剂量-反应关联。结果：在平均2.72年的随访期间，6990名参与者出现高血压。在完全调整的模型中，与CVAI三分位数（HR = 1.26, 95% CI: 1.19-1.34）的参与者相比，CVAI三分位数（HR = 1.26, 95% CI: 1.19-1.34）的参与者与高血压发生风险增加相关，每标准差（SD）的增加与高血压发生风险增加12% （HR = 1.12, 95% CI: 1.09-1.15）相关。在亚组和敏感性分析中也观察到类似的显著相关性。此外，RCS分析显示CVAI与高血压发生风险存在显著的剂量-反应相关性（总体P < 0.001，非线性P = 0.238）。结论：这些结果表明CVAI与老年人高血压发病风险呈正相关。

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来源期刊

High Blood Pressure & Cardiovascular Prevention PERIPHERAL VASCULAR DISEASE-

CiteScore

5.70

自引率

3.30%

发文量

期刊介绍： High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes: Invited ''State of the Art'' reviews. Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.