Ethnic differences in adipose tissue dysfunction and insulin resistance: a scoping review

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-08-06 DOI:10.1016/j.diabres.2025.112363

Mohammad AlShehab, Adele Costabile, Michael Patterson, Olah Hakim

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引用次数: 0

Abstract

Aims

The objective of this scoping review is to synthesize ethnic comparison studies focused on characteristics of adipose tissue dysfunction including ectopic fat, adipokines and insulin resistance in populations of south Asian (SA), black (BA) and white (WE) ethnicity.

Methods

A search of the literature was conducted on MEDLINE using keywords for adipose tissue dysfunction and ethnicity. Studies were included if they compared ectopic fat in adults (>18-years) of SA, BA or WE ethnicity, with data on insulin sensitivity and adipokines extracted where present.

Results

Thirty-one studies were included in this review. Trends showed most studies were conducted in USA (n = 22); BA were the focus of most ethnic comparison studies (n = 28). Most studies focused on intrahepatic lipids (n = 26), with fewer investigating intrapancreatic lipids (n = 3) and intramyocellular lipids (n = 8). Only 2 studies investigated leptin and adiponectin alongside ectopic fat deposition by ethnicity.

Conclusions

Current trends indicate intrahepatic lipid is lower in BA but greater in SA compared to WE populations, indicting possible ethnic disparities in the role ATD in the development of T2D. Few ethnicity studies have investigated multiple characteristics of ATD between BA and SA groups in a single study which may be needed to elucidate ethnic-specific pathophysiology of T2D.

查看原文本刊更多论文

脂肪组织功能障碍和胰岛素抵抗的种族差异：范围综述。

目的：本综述的目的是综合种族比较研究，重点关注南亚（SA）、黑人（BA）和白人（WE）人群中脂肪组织功能障碍的特征，包括异位脂肪、脂肪因子和胰岛素抵抗。方法：在MEDLINE上以脂肪组织功能障碍和种族为关键词进行文献检索。如果将SA、BA或WE种族的成人（bb - 18岁）的异位脂肪与胰岛素敏感性和提取的脂肪因子的数据进行比较，则纳入研究。结果：本综述纳入了31项研究。趋势显示大多数研究是在美国进行的（n = 22）；BA是大多数种族比较研究的重点（n = 28）。大多数研究集中于肝内脂质（n = 26），较少研究胰腺内脂质（n = 3）和细胞内脂质（n = 8）。只有2项研究调查了瘦素和脂联素与异位脂肪沉积的关系。结论：目前的趋势表明，与WE人群相比，BA人群的肝内脂质较低，而SA人群的肝内脂质较高，这表明ATD在T2D发展中的作用可能存在种族差异。很少有种族研究在单一研究中调查BA和SA组之间ATD的多个特征，这可能需要阐明T2D的种族特异性病理生理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.