Effectiveness of active warming interventions in preventing perioperative hypothermia and its complications in cancer patients: A systematic review and meta-analysis.

IF 2.9 2区医学 Q2 ONCOLOGY

Ejso Pub Date : 2025-10-01 Epub Date: 2025-07-19 DOI:10.1016/j.ejso.2025.110329

Saili Wu, Yingxue Bao

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引用次数: 0

Abstract

Background: Perioperative hypothermia is a common complication during cancer surgeries, associated with adverse outcomes such as shivering, prolonged recovery, and increased length of stay (LOS). This systematic review and meta-analysis aimed to assess the effectiveness of active warming interventions in preventing perioperative hypothermia and its complications.

Methods: In this systematic review and meta-analysis, articles published up to 2025 January 2, were searched in Scopus, PubMed, Web of Science, and Cochrane Library databases. Outcomes measured included perioperative core body temperature, shivering, blood losing, and LOS. Heterogeneity was assessed using the I² statistic, and publication bias was evaluated with funnel plots and Egger's test. Meta-regression and subgroup analyses explored potential predictors of effectiveness.

Results: Out of 2650 records, 20 articles were included. Active warming techniques improved core body temperature, with a Standard Mean Difference (SMD) of 0.65 at 30 min, increasing to 2.14 at 180 min. Shivering incidence was significantly reduced, with risk differences ranging from -0.12 to -0.25 across interventions. LOS was reduced by an average of 6 h, with a significant difference observed in combined interventions (SMD = -0.80, 95 % CI: 1.23 to -0.37). Heterogeneity was high for pharmaceutical interventions (I² > 75 %), whereas it remained low for non-pharmacological interventions (I² < 50 %). Meta-regression revealed participant mean age, %male, BMI, and surgery duration cannot significantly predict the SMD between the two groups.

Conclusion: Although, the results of this study show active warming interventions can be effective in preventing perioperative hypothermia complications, more studies with larger samples and higher quality are needed.

Study registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420250651763.

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主动升温干预预防癌症患者围手术期低温及其并发症的有效性：一项系统综述和荟萃分析。

背景：围手术期低温是癌症手术中常见的并发症，与寒战、恢复时间延长和住院时间（LOS）增加等不良结果相关。本系统综述和荟萃分析旨在评估主动升温干预在预防围手术期低温及其并发症中的有效性。方法：在本系统综述和荟萃分析中，检索了Scopus、PubMed、Web of Science和Cochrane Library数据库中截至2025年1月2日发表的文章。测量的结果包括围手术期核心体温、颤抖、失血量和LOS。异质性评价采用I2统计量，发表偏倚评价采用漏斗图和Egger检验。meta回归和亚组分析探讨了潜在的疗效预测因素。结果：共纳入2650篇文献20篇。主动升温技术提高了核心体温，30分钟时的标准均差（SMD）为0.65,180分钟时增加到2.14。寒战发生率显著降低，不同干预措施的风险差异从-0.12到-0.25不等。LOS平均减少了6小时，在联合干预中观察到显著差异（SMD = -0.80, 95% CI: 1.23至-0.37）。药物干预的异质性很高（I2 > 75%），而非药物干预的异质性仍然很低(I2结论：尽管本研究结果表明主动升温干预可以有效预防围手术期低体温并发症，但需要更多更大样本和更高质量的研究。研究注册：https://www.crd.york.ac.uk/PROSPERO/view/CRD420250651763。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ejso 医学-外科

CiteScore

6.40

自引率

2.60%

发文量

1148

审稿时长

41 days

期刊介绍： JSO - European Journal of Surgical Oncology ("the Journal of Cancer Surgery") is the Official Journal of the European Society of Surgical Oncology and BASO ~ the Association for Cancer Surgery. The EJSO aims to advance surgical oncology research and practice through the publication of original research articles, review articles, editorials, debates and correspondence.