Proteomic approaches for biomarker discovery and clinical applications in autoimmune diseases.

IF 2.9 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Clinica Chimica Acta Pub Date : 2026-01-01 Epub Date: 2025-08-06 DOI:10.1016/j.cca.2025.120533
Sultan Ayesh Mohammed Saghir, Amir M Al Hroob, Salah A Alshehade, Sulaiman Alnaimat, Nuha A Al Yousfi, Sarah Ahmad Bahjat Al-Rawashdeh, Mohammad Ahmad Al Rawashdeh, Mohammed Abdullah Alshawsh
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引用次数: 0

Abstract

Autoimmune diseases (ADs) impact approximately 3% of the global population. It encompasses more than 80 chronic, often debilitating conditions resulting from immune system defects that lead the body to attack its tissues. Although many ADs are rare, their prevalence is rising. Despite advancements, ADs diagnosis and classification still rely heavily on clinical examination combined with conventional laboratory testing and imaging. Emerging proteomic screening, technologies now offer the potential to identify unique biomarkers for more precise diagnosis, classification, and treatment decisions. Protein profiling, an advancing area within proteomics, provides unparalleled insights into biological processes underlying these diseases. Thus, this review highlights recent developments in proteomic and genetic profiling for ADs pathogenesis, diagnosis, and treatment challenges, focusing on the clinical utility of proteomic techniques in prognosis, diagnosis, and therapeutic guidance. Notably, discovering new biomarkers through proteomic screening is crucial for creating robust multi-parameter assays, which enhance diagnostic accuracy and treatment decisions in ADs.

自身免疫性疾病中生物标志物发现和临床应用的蛋白质组学方法。
自身免疫性疾病(ADs)影响着全球约3%的人口。它包括80多种慢性疾病,通常是由免疫系统缺陷引起的,导致身体攻击其组织。尽管许多ad很罕见,但患病率正在上升。尽管取得了进步,但ad的诊断和分类仍然严重依赖临床检查结合传统的实验室检查和影像学检查。新兴的蛋白质组筛选技术现在提供了识别独特生物标志物的潜力,以更精确的诊断、分类和治疗决策。蛋白质分析是蛋白质组学的一个前沿领域,它为这些疾病背后的生物过程提供了无与伦比的见解。因此,本文重点介绍了蛋白质组学和遗传图谱在ad发病机制、诊断和治疗方面的最新进展,重点介绍了蛋白质组学技术在预后、诊断和治疗指导方面的临床应用。值得注意的是,通过蛋白质组学筛选发现新的生物标志物对于创建可靠的多参数分析至关重要,这可以提高ad的诊断准确性和治疗决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinica Chimica Acta
Clinica Chimica Acta 医学-医学实验技术
CiteScore
10.10
自引率
2.00%
发文量
1268
审稿时长
23 days
期刊介绍: The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.
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