Effects of Resistance Training at Different Intensities on Preventing Breast Cancer-Related Lymphedema: A 1-Year Randomized Controlled Trial.

IF 2.5 3区医学 Q2 ONCOLOGY

Clinical breast cancer Pub Date : 2025-07-14 DOI:10.1016/j.clbc.2025.07.012

Yi-Jing Fan, Hui-Qian Xu, Hong Li, Zi-Rui Zhang, Shu-Fang Zhang, Ai-Jun Du, Li-Zhi Zhou, Yang Wang

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Abstract

Background: Breast cancer-related lymphedema (BCRL) is a relatively common and harmful complication after breast cancer surgery, and there is currently no effective cure. We hypothesized that, compared with the control group, 12 weeks of resistance exercise at different intensities could reduce the incidence of BCRL after axillary lymph node dissection.

Methods: 114 breast cancer patients undergoing axillary lymph node dissection were randomly divided into a Control Group (CG), a Low-to-Moderate Intensity Exercise Group (L-MIEG, 40%-70% 1-RM) and a Moderate-to-High Intensity Exercise Group (M-HIEG, 60%-85% 1-RM).

Results: (1) The 12-month cumulative BCRL incidence was higher in the CG (16.3%, 6/37) than in the L-MIEG (8.3%, 3/36) and M-HIEG (5.5%, 2/37). (2) Postintervention and at 6-and 12- month follow-ups, both intervention groups had smaller interlimb differences than the CG (P < .05), and the M-HIEG had smaller differences at 6-month than the L-MIEG (P < .05). (3) InBody analysis showed both intervention groups outperformed CG in segmental water differences, extracellular water (ECW), and single-frequency bioelectrical impedance analysis (SFBIA) (P < .05), and the M-HIEG was better at 6-month (P < .05). (4) At 6-and 12-month follow-ups, both intervention groups improved grip strength more than CG (P < .05), and the M-HIEG was superior at 12 months (P < .05).

Conclusions: Different- intensity resistance exercises benefit BCRL prevention, with M-HIEG being more effective.

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不同强度的阻力训练对预防乳腺癌相关淋巴水肿的影响：一项为期1年的随机对照试验

背景：乳腺癌相关淋巴水肿（Breast cancer-related lymphodema， BCRL）是乳腺癌手术后较为常见和有害的并发症，目前尚无有效的治疗方法。我们假设，与对照组相比，12周不同强度的阻力运动可以降低腋窝淋巴结清扫后BCRL的发生率。方法：114例行腋窝淋巴结清扫术的乳腺癌患者随机分为对照组（CG）、中低强度运动组（L-MIEG, 40% ~ 70% 1-RM）和中高强度运动组（M-HIEG, 60% ~ 85% 1-RM）。结果：(1)CG组12个月累积BCRL发生率（16.3%,6/37）高于L-MIEG组（8.3%,3/36）和M-HIEG组（5.5%,2/37）。(2)干预后及随访6、12个月时，两组患者肢间差异均小于对照组（P < 0.05），且6个月时M-HIEG差异小于L-MIEG （P < 0.05）。(3) InBody分析显示，两组在节段水差、细胞外水（ECW）和单频生物电阻抗分析（SFBIA）方面均优于CG (P < 0.05)，且M-HIEG在6个月时优于CG （P < 0.05）。(4)随访6个月和12个月时，两组握力的改善均优于对照组（P < 0.05）， 12个月时M-HIEG更优于对照组（P < 0.05）。结论：不同强度的阻力运动有利于预防BCRL，其中M-HIEG更有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical breast cancer 医学-肿瘤学

CiteScore

5.40

自引率

3.20%

发文量

174

审稿时长

48 days

期刊介绍： Clinical Breast Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of breast cancer. Clinical Breast Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of breast cancer. The main emphasis is on recent scientific developments in all areas related to breast cancer. Specific areas of interest include clinical research reports from various therapeutic modalities, cancer genetics, drug sensitivity and resistance, novel imaging, tumor genomics, biomarkers, and chemoprevention strategies.